MetaCyc Pathway: adipate degradation in Pseudomonas fluorescens FW300-N2E3

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Reactions and Genes butyrate (C)
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Succinate--CoA ligase (ADP-forming):
adipate + ATP + coenzyme A→adipoyl-CoA + ADP + phosphate (EC 6.2.1.5)
AO353_01815 N.D.
AO353_01820 N.D.
adipoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-5-carboxy-2-pentenoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
AO353_06340 +0.2
AO353_07485 -3.7
AO353_07495 +0.8
AO353_12805 +0.0
AO353_21065 -0.2
Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H2O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)
AO353_00510 -1.5
AO353_01135 -0.5
AO353_01155 +0.0
AO353_03780 -0.0
AO353_17555 -0.1
AO353_19125 N.D.
AO353_23055 +0.1
AO353_24830 -0.5
AO353_25665 +0.3
AO353_25675 N.D.
AO353_26540 -0.3
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipoyl-CoA + NADH + H+ (EC 1.1.1.35)
AO353_00510 -1.5
AO353_01155 +0.0
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)
AO353_17205 -1.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information