| Reactions and Genes | butyrate (C) |
|---|
| remove |
sn-glycerol-1-phosphate dehydrogenase (in reverse):
glycerone phosphate + NAD(P)H + H+→sn-glycerol 1-phosphate + NAD(P)+ (EC 1.1.1.261) |
| No genes |
Carbon-monoxide dehydrogenase (ferredoxin) (in reverse):
CO2 + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→carbon monoxide + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O (EC 1.2.7.4; 2.3.3.M4; 2.3.3.M5) |
| No genes |
| CO2 + NADPH→formate + NADP+ (EC 1.17.1.10) |
| No genes |
| CO2 + a methanofuran + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→a formylmethanofuran + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O (EC 1.2.7.12) |
| No genes |
Carbonate dehydratase (in reverse):
CO2 + H2O→hydrogen carbonate + H+ (EC 4.2.1.1) |
| AO353_10145 | +0.0 |
| AO353_10815 | -0.1 |
| AO353_14595 | -0.7 |
| AO353_25445 | +0.2 |
| AO353_27095 | +0.1 |
Formylmethanofuran--tetrahydromethanopterin N-formyltransferase:
a formylmethanofuran + tetrahydromethanopterin + H+→5-formyl-tetrahydromethanopterin + a methanofuran (EC 2.3.1.101) |
| No genes |
Formate--tetrahydrofolate ligase:
formate + ATP + a tetrahydrofolate→an N10-formyltetrahydrofolate + ADP + phosphate (EC 6.3.4.3) |
| No genes |
Methenyltetrahydromethanopterin cyclohydrolase (in reverse):
5-formyl-tetrahydromethanopterin + H+→5,10-methenyltetrahydromethanopterin + H2O (EC 3.5.4.27) |
| No genes |
Methenyltetrahydrofolate cyclohydrolase (in reverse):
an N10-formyltetrahydrofolate + H+→a 5,10-methenyltetrahydrofolate + H2O (EC 3.5.4.9) |
| AO353_20145 | N.D. |
5,10-methenyltetrahydromethanopterin hydrogenase:
5,10-methenyltetrahydromethanopterin + H2→5,10-methylene-tetrahydromethanopterin + H+ (EC 1.12.98.2) |
| No genes |
Methylenetetrahydrofolate dehydrogenase (NADP(+)) (in reverse):
a 5,10-methenyltetrahydrofolate + NADPH→a 5,10-methylenetetrahydrofolate + NADP+ (EC 1.5.1.5) |
| AO353_20145 | N.D. |
| 5,10-methylene-tetrahydromethanopterin + a reduced factor 420→5-methyltetrahydromethanopterin + an oxidized factor 420 (EC 1.5.98.2) |
| No genes |
| a 5,10-methylenetetrahydrofolate + 2 NADH + 2 an oxidized ferredoxin [iron-sulfur] cluster→a 5-methyltetrahydrofolate + 2 NAD+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.5.1.M4) |
| No genes |
| a 5,10-methylenetetrahydrofolate + NADH + H+→a 5-methyltetrahydrofolate + NAD+ (EC 1.5.1.54) |
| AO353_08015 | -3.2 |
Methylenetetrahydrofolate reductase (ferredoxin) (in reverse):
a 5,10-methylenetetrahydrofolate + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→a 5-methyltetrahydrofolate + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.5.7.1) |
| No genes |
| a 5-methyltetrahydrofolate + a [Co(I) corrinoid Fe-S protein] + H+→a [methyl-Co(III) corrinoid Fe-S protein] + a tetrahydrofolate (EC 2.1.1.258) |
| No genes |
| CO2 + 5-methyltetrahydromethanopterin + coenzyme A + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→tetrahydromethanopterin + acetyl-CoA + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O (EC 2.3.3.M4) |
| No genes |
CO-methylating acetyl-CoA synthase (in reverse):
carbon monoxide + a [methyl-Co(III) corrinoid Fe-S protein] + coenzyme A→acetyl-CoA + a [Co(I) corrinoid Fe-S protein] + H+ (EC 2.3.1.169; 2.3.3.M4; 2.3.3.M5) |
| No genes |
Pyruvate synthase (in reverse):
acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.2.7.1) |
| No genes |
Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9) |
| AO353_00505 | -0.5 |
| AO353_01065 | +3.0 |
| AO353_01160 | +0.1 |
| AO353_05785 | +0.0 |
| AO353_13880 | +0.1 |
| AO353_17205 | -1.2 |
| AO353_25685 | -2.7 |
| AO353_27530 | -2.4 |
| AO353_27945 | -0.2 |
Alanine transaminase (in reverse):
pyruvate + L-glutamate→L-alanine + 2-oxoglutarate (EC 2.6.1.2) |
| AO353_03235 | +0.1 |
| AO353_19150 | +0.1 |
Pyruvate, water dikinase:
pyruvate + ATP + H2O→phosphoenolpyruvate + AMP + 2 H+ + phosphate (EC 2.7.9.2) |
| AO353_00865 | +0.1 |
Pyruvate carboxylase:
hydrogen carbonate + pyruvate + ATP→oxaloacetate + ADP + H+ + phosphate (EC 6.4.1.1) |
| AO353_10025 | -3.7 |
| AO353_10030 | -3.5 |
Phosphopyruvate hydratase (in reverse):
phosphoenolpyruvate + H2O→2-phospho-D-glycerate (EC 4.2.1.11) |
| AO353_16560 | N.D. |
Hydroxymethylglutaryl-CoA synthase:
acetoacetyl-CoA + acetyl-CoA + H2O→(S)-3-hydroxy-3-methylglutaryl-CoA + coenzyme A + H+ (EC 2.3.3.10) |
| No genes |
Phosphoenolpyruvate carboxylase (in reverse):
hydrogen carbonate + phosphoenolpyruvate→oxaloacetate + phosphate (EC 4.1.1.31) |
| AO353_16310 | -2.5 |
Hydroxymethylglutaryl-CoA reductase (NADPH) (in reverse):
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+→(R)-mevalonate + coenzyme A + 2 NADP+ (EC 1.1.1.34) |
| No genes |
| 2-phospho-D-glycerate→3-phospho-D-glycerate (EC 5.4.2.12) |
| AO353_12115 | -3.8 |
Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1) |
| AO353_01120 | +0.1 |
| AO353_01210 | -0.2 |
| AO353_01655 | +0.0 |
| AO353_02295 | +0.0 |
| AO353_09180 | -0.0 |
| AO353_09990 | -0.3 |
| AO353_15915 | -0.0 |
| AO353_17700 | -0.1 |
| AO353_18575 | +0.2 |
| AO353_19150 | +0.1 |
| AO353_20995 | -0.1 |
| AO353_22840 | -0.0 |
| AO353_22920 | +0.2 |
| AO353_23080 | -0.0 |
| AO353_24850 | -0.4 |
| AO353_26890 | +0.1 |
| AO353_28150 | +0.2 |
| AO353_29325 | -0.1 |
Malate dehydrogenase (in reverse):
oxaloacetate + NADH + H+→(S)-malate + NAD+ (EC 1.1.1.37; 1.1.1.38) |
| No genes |
Glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) (in reverse):
3-phospho-D-glycerate + 3 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→D-glyceraldehyde 3-phosphate + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O (EC 1.2.7.6) |
| No genes |
Fumarate hydratase:
(S)-malate→fumarate + H2O (EC 4.2.1.2) |
| AO353_02150 | -0.2 |
| AO353_03795 | +0.7 |
Mevalonate kinase:
(R)-mevalonate + ATP→(R)-5-phosphomevalonate + ADP + H+ (EC 2.7.1.36) |
| No genes |
Phosphomevalonate kinase:
(R)-5-phosphomevalonate + ATP→(R)-mevalonate diphosphate + ADP (EC 2.7.4.2) |
| No genes |
Succinate dehydrogenase (ubiquinone):
fumarate[in] + a menaquinol→succinate[in] + a menaquinone (EC 1.3.5.1) |
| No genes |
Triose-phosphate isomerase:
D-glyceraldehyde 3-phosphate→glycerone phosphate (EC 5.3.1.1) |
| AO353_05590 | N.D. |
| AO353_21370 | +0.0 |
Diphosphomevalonate decarboxylase:
(R)-mevalonate diphosphate + ATP→3-methylbut-3-en-1-yl diphosphate + CO2 + ADP + phosphate (EC 4.1.1.33) |
| No genes |
Fructose-bisphosphate aldolase (in reverse):
glycerone phosphate + D-glyceraldehyde 3-phosphate→β-D-fructofuranose 1,6-bisphosphate (EC 4.1.2.13) |
| AO353_07930 | N.D. |
Succinate--CoA ligase (ADP-forming):
succinate + ATP + coenzyme A→succinyl-CoA + ADP + phosphate (EC 6.2.1.5) |
| AO353_01815 | N.D. |
| AO353_01820 | N.D. |
2-oxoglutarate synthase (in reverse):
succinyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→2-oxoglutarate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.2.7.3) |
| No genes |
Isopentenyl-diphosphate Delta-isomerase:
3-methylbut-3-en-1-yl diphosphate→prenyl diphosphate (EC 5.3.3.2) |
| AO353_19625 | +0.1 |
ADP-specific phosphofructokinase (in reverse):
β-D-fructofuranose 1,6-bisphosphate + AMP + H+→β-D-fructofuranose 6-phosphate + ADP (EC 2.7.1.146) |
| No genes |
Dimethylallyltranstransferase:
prenyl diphosphate + 3-methylbut-3-en-1-yl diphosphate→geranyl diphosphate + diphosphate (EC 2.5.1.1) |
| AO353_06650 | N.D. |
| AO353_14095 | N.D. |
Glucose-6-phosphate isomerase (in reverse):
β-D-fructofuranose 6-phosphate→α-D-glucose 6-phosphate (EC 5.3.1.9) |
| AO353_14370 | -1.9 |
Geranyltranstransferase:
geranyl diphosphate + 3-methylbut-3-en-1-yl diphosphate→(2E,6E)-farnesyl diphosphate + diphosphate (EC 2.5.1.10) |
| AO353_06650 | N.D. |
| AO353_14095 | N.D. |
Farnesyltranstransferase:
(2E,6E)-farnesyl diphosphate + 3-methylbut-3-en-1-yl diphosphate→geranylgeranyl diphosphate + diphosphate (EC 2.5.1.29) |
| AO353_06650 | N.D. |
| AO353_14095 | N.D. |
Phosphoglycerol geranylgeranyltransferase:
geranylgeranyl diphosphate + sn-glycerol 1-phosphate→sn-3-(O-geranylgeranyl)glycerol 1-phosphate + diphosphate (EC 2.5.1.41) |
| No genes |
Geranylgeranylglycerol-phosphate geranylgeranyltransferase:
geranylgeranyl diphosphate + sn-3-(O-geranylgeranyl)glycerol 1-phosphate→2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + diphosphate (EC 2.5.1.42) |
| No genes |
| 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + 8 NAD(P)H + 8 H+→2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + 8 NAD(P)+ (EC 1.3.1.101) |
| No genes |
| 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + 16 H+ + 16 a reduced ferredoxin [iron-sulfur] cluster→2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + 16 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.3.7.11) |
| No genes |
CDP-archaeol synthase:
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + CTP + H+→CDP-2,3-bis-O-geranylgeranyl-sn-glycerol + diphosphate (EC 2.7.7.67) |
| No genes |
CDP-archaeol synthase:
2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + CTP + H+→CDP-2,3-bis-O-phytanyl-sn-glycerol + diphosphate (EC 2.7.7.67) |
| No genes |
| CDP-2,3-bis-O-geranylgeranyl-sn-glycerol + L-serine→2,3-bis-O-geranylgeranyl-sn-glycero-1-phosphoserine + CMP + H+ (EC 2.7.8.38) |
| No genes |
| 2,3-bis-O-geranylgeranyl-sn-glycero-1-phosphoserine + H+→2,3-bis-O-geranylgeranyl-sn-glycero-1-phosphoethanolamine + CO2 |
| No genes |
| CDP-2,3-bis-O-phytanyl-sn-glycerol + L-serine→2,3-bis-O-phytanyl-sn-glycero-1-phosphoserine + CMP + H+ (EC 2.7.8.38) |
| No genes |
| 2,3-bis-O-phytanyl-sn-glycero-1-phosphoserine + H+→2,3-bis-O-phytanyl-sn-glycero-1-phosphoethanolamine + CO2 |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information