MetaCyc Pathway: superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) in Pseudomonas fluorescens FW300-N2E3

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Reactions and Genes butyrate (C)
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
AO353_00505 -0.5
AO353_01065 +3.0
AO353_01160 +0.1
AO353_05785 +0.0
AO353_13880 +0.1
AO353_17205 -1.2
AO353_25685 -2.7
AO353_27530 -2.4
AO353_27945 -0.2
Hydroxymethylglutaryl-CoA synthase:
acetoacetyl-CoA + acetyl-CoA + H2O→(S)-3-hydroxy-3-methylglutaryl-CoA + coenzyme A + H+ (EC 2.3.3.10)
No genes
Hydroxymethylglutaryl-CoA reductase (NADPH) (in reverse):
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+→(R)-mevalonate + coenzyme A + 2 NADP+ (EC 1.1.1.34)
No genes
Mevalonate kinase:
(R)-mevalonate + ATP→(R)-5-phosphomevalonate + ADP + H+ (EC 2.7.1.36)
No genes
Phosphomevalonate kinase:
(R)-5-phosphomevalonate + ATP→(R)-mevalonate diphosphate + ADP (EC 2.7.4.2)
No genes
Diphosphomevalonate decarboxylase:
(R)-mevalonate diphosphate + ATP→3-methylbut-3-en-1-yl diphosphate + ADP + CO2 + phosphate (EC 4.1.1.33)
No genes
Isopentenyl-diphosphate Delta-isomerase:
3-methylbut-3-en-1-yl diphosphate→prenyl diphosphate (EC 5.3.3.2)
AO353_19625 +0.1
Dimethylallyltranstransferase:
prenyl diphosphate + 3-methylbut-3-en-1-yl diphosphate→geranyl diphosphate + diphosphate (EC 2.5.1.1)
AO353_06650 N.D.
AO353_14095 N.D.
Geranyltranstransferase:
geranyl diphosphate + 3-methylbut-3-en-1-yl diphosphate→(2E,6E)-farnesyl diphosphate + diphosphate (EC 2.5.1.10)
AO353_06650 N.D.
AO353_14095 N.D.
Farnesyltranstransferase:
(2E,6E)-farnesyl diphosphate + 3-methylbut-3-en-1-yl diphosphate→geranylgeranyl diphosphate + diphosphate (EC 2.5.1.29)
AO353_06650 N.D.
AO353_14095 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information