MetaCyc Pathway: pyruvate fermentation to butanol II (engineered) in Klebsiella michiganensis M5al

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Reactions and Genes L-Glutamine (C)
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
BWI76_RS01360 -0.0
BWI76_RS13135 +0.4
BWI76_RS16135 -0.5
BWI76_RS20460 -0.1
BWI76_RS23445 +0.0
BWI76_RS23710 -0.4
3-hydroxyacyl-CoA dehydrogenase (in reverse):
acetoacetyl-CoA + NADH + H+→(S)-3-hydroxybutanoyl-CoA + NAD+ (EC 1.1.1.35)
BWI76_RS01365 +0.2
BWI76_RS01370 N.D.
BWI76_RS20455 +0.1
(S)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.150)
BWI76_RS01365 +0.2
BWI76_RS01370 N.D.
BWI76_RS20455 +0.1
Trans-2-enoyl-CoA reductase (NAD(+)) (in reverse):
crotonyl-CoA + NADH + H+→butanoyl-CoA + NAD+ (EC 1.3.1.44)
BWI76_RS05470 -1.3
BWI76_RS16860 -0.1
Butanal dehydrogenase (in reverse):
butanoyl-CoA + NAD(P)H + H+→1-butanal + coenzyme A + NAD(P)+ (EC 1.2.1.57)
No genes
1-butanal + NADH + H+→butan-1-ol + NAD+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information