MetaCyc Pathway: colanic acid building blocks biosynthesis in Azospirillum brasilense Sp245

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Reactions and Genes L-Malic (C) with ammonium chloride; anaerobic; 8 days
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Glucose-6-phosphate isomerase:
α-D-glucose 6-phosphate→β-D-fructofuranose 6-phosphate (EC 5.3.1.9)
AZOBR_RS05045 N.D.
Phosphoglucomutase (in reverse):
D-glucopyranose 6-phosphate→α-D-glucopyranose 1-phosphate (EC 5.4.2.2)
AZOBR_RS02670 -0.0
AZOBR_RS07040 N.D.
UTP-monosaccharide-1-phosphate uridylyltransferase:
α-D-glucopyranose 1-phosphate + H+ + UTP→UDP-α-D-glucose + diphosphate (EC 2.7.7.64; 2.7.7.9)
AZOBR_RS31075 N.D.
Mannose-6-phosphate isomerase (in reverse):
β-D-fructofuranose 6-phosphate→D-mannopyranose 6-phosphate (EC 5.3.1.8)
AZOBR_RS33830 -1.9
Phosphomannomutase (in reverse):
D-mannopyranose 6-phosphate→α-D-mannose 1-phosphate (EC 5.4.2.8)
AZOBR_RS33725 -0.2
UDP-glucose 4-epimerase:
UDP-α-D-glucose→UDP-α-D-galactose (EC 5.1.3.2)
AZOBR_RS09095 N.D.
AZOBR_RS09110 N.D.
AZOBR_RS17210 +0.5
AZOBR_RS17355 -0.0
AZOBR_RS22395 -0.1
AZOBR_RS22915 +0.1
AZOBR_RS27510 -0.0
AZOBR_RS28355 -0.1
AZOBR_RS33555 -0.6
AZOBR_RS33600 -1.4
AZOBR_RS33630 -0.9
UDP-glucose 6-dehydrogenase:
UDP-α-D-glucose + 2 NAD+ + H2O→UDP-α-D-glucuronate + 2 NADH + 3 H+ (EC 1.1.1.22)
AZOBR_RS03380 -0.1
AZOBR_RS23650 -0.2
AZOBR_RS33565 -2.6
AZOBR_RS33720 N.D.
Mannose-1-phosphate guanylyltransferase:
α-D-mannose 1-phosphate + GTP + H+→GDP-α-D-mannose + diphosphate (EC 2.7.7.13)
AZOBR_RS33830 -1.9
GDP-mannose 4,6-dehydratase:
GDP-α-D-mannose→GDP-4-dehydro-α-D-rhamnose + H2O (EC 4.2.1.47)
AZOBR_RS33395 -0.7
AZOBR_RS33465 -2.7
GDP-L-fucose synthase:
GDP-4-dehydro-α-D-rhamnose→GDP-4-dehydro-6-deoxy-β-L-galactose (EC 1.1.1.271)
AZOBR_RS03370 +0.1
GDP-L-fucose synthase (in reverse):
GDP-4-dehydro-6-deoxy-β-L-galactose + NADPH + H+→GDP-β-L-fucose + NADP+ (EC 1.1.1.271)
AZOBR_RS03370 +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information