MetaCyc Pathway: superpathway of L-threonine biosynthesis in Pseudomonas fluorescens FW300-N2E3

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Reactions and Genes L-Phenylalanine (C)
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
AO353_01120 +0.0
AO353_01210 -0.3
AO353_01655 -0.1
AO353_02295 +0.2
AO353_09180 +0.1
AO353_09990 +0.1
AO353_15915 +0.1
AO353_17700 +0.1
AO353_18575 -3.2
AO353_19150 -0.1
AO353_20995 -0.1
AO353_22840 -0.0
AO353_22920 -0.4
AO353_23080 +0.0
AO353_24850 -0.1
AO353_26890 +0.0
AO353_28150 +0.3
AO353_29325 -0.2
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
AO353_02975 -0.3
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
AO353_17160 +0.0
AO353_20640 N.D.
AO353_20645 -0.5
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
AO353_04355 -1.6
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
AO353_00930 -0.1
AO353_10920 N.D.
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1)
AO353_04350 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information