MetaCyc Pathway: L-tyrosine degradation V (reductive Stickland reaction) in Pseudomonas fluorescens FW300-N2E3

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Reactions and Genes L-Phenylalanine (C)
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Aspartate transaminase:
L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
AO353_01120 +0.0
AO353_01210 -0.3
AO353_01655 -0.1
AO353_02065 -0.2
AO353_02295 +0.2
AO353_05105 -1.4
AO353_09180 +0.1
AO353_09990 +0.1
AO353_15915 +0.1
AO353_17700 +0.1
AO353_18575 -3.2
AO353_19150 -0.1
AO353_20540 +0.0
AO353_20995 -0.1
AO353_22840 -0.0
AO353_22920 -0.4
AO353_23080 +0.0
AO353_24850 -0.1
AO353_26890 +0.0
AO353_28150 +0.3
AO353_29325 -0.2
Indolelactate dehydrogenase (in reverse):
3-(4-hydroxyphenyl)pyruvate + NADH + H+→(R)-3-(4-hydroxyphenyl)lactate + NAD+ (EC 1.1.1.110)
No genes
Cinnamoyl-CoA:phenyllactate CoA-transferase:
(R)-3-(4-hydroxyphenyl)lactate + (E)-4-coumaroyl-CoA→4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA (EC 2.8.3.17)
No genes
4-coumarate + a reduced electron-transfer flavoprotein→phloretate + an oxidized electron-transfer flavoprotein + H+ (EC 1.3.8.15)
No genes
(R)-3-(4-hydroxyphenyl)lactoyl-CoA→(E)-4-coumaroyl-CoA + H2O (EC 4.2.1.175)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information