MetaCyc Pathway: superpathway of aromatic amino acid biosynthesis in Pseudomonas fluorescens FW300-N2E3

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Reactions and Genes L-Phenylalanine (C)
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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
AO353_19030 +0.4
AO353_19115 -0.8
AO353_21815 -0.3
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
AO353_12505 N.D.
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
AO353_06170 -0.3
AO353_13685 -1.3
AO353_16560 N.D.
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
AO353_06175 -0.4
AO353_10670 -3.2
AO353_19825 +0.0
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
AO353_12500 -2.8
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
AO353_02060 -0.9
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
AO353_02250 -2.3
Anthranilate synthase:
chorismate + L-glutamine→anthranilate + L-glutamate + H+ + pyruvate (EC 4.1.3.27)
AO353_07220 -2.5
AO353_07230 -3.7
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
AO353_02070 -0.0
AO353_12165 +0.1
Prephenate dehydratase:
prephenate + H+→3-phenyl-2-oxopropanoate + CO2 + H2O (EC 4.2.1.51)
AO353_02070 -0.0
AO353_17845 +0.0
Prephenate dehydrogenase:
prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)
AO353_02060 -0.9
Anthranilate phosphoribosyltransferase (in reverse):
anthranilate + 5-phospho-α-D-ribose 1-diphosphate→N-(5-phosphoribosyl)-anthranilate + diphosphate (EC 2.4.2.18)
AO353_07215 -3.7
AO353_27615 -0.4
Phosphoribosylanthranilate isomerase:
N-(5-phosphoribosyl)-anthranilate→1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (EC 5.3.1.24)
AO353_20665 -3.0
Aspartate transaminase (in reverse):
3-phenyl-2-oxopropanoate + L-glutamate→L-phenylalanine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
AO353_01120 +0.0
AO353_01210 -0.3
AO353_01655 -0.1
AO353_02065 -0.2
AO353_02295 +0.2
AO353_05105 -1.4
AO353_09180 +0.1
AO353_09990 +0.1
AO353_15915 +0.1
AO353_17700 +0.1
AO353_18575 -3.2
AO353_19150 -0.1
AO353_20540 +0.0
AO353_20995 -0.1
AO353_22840 -0.0
AO353_22920 -0.4
AO353_23080 +0.0
AO353_24850 -0.1
AO353_26890 +0.0
AO353_28150 +0.3
AO353_29325 -0.2
Aspartate transaminase (in reverse):
3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
AO353_01120 +0.0
AO353_01210 -0.3
AO353_01655 -0.1
AO353_02065 -0.2
AO353_02295 +0.2
AO353_05105 -1.4
AO353_09180 +0.1
AO353_09990 +0.1
AO353_15915 +0.1
AO353_17700 +0.1
AO353_18575 -3.2
AO353_19150 -0.1
AO353_20540 +0.0
AO353_20995 -0.1
AO353_22840 -0.0
AO353_22920 -0.4
AO353_23080 +0.0
AO353_24850 -0.1
AO353_26890 +0.0
AO353_28150 +0.3
AO353_29325 -0.2
Indole-3-glycerol-phosphate synthase:
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+→(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O (EC 4.1.1.48)
AO353_07210 -3.9
Indole-3-glycerol-phosphate lyase:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate→indole + D-glyceraldehyde 3-phosphate (EC 4.1.2.8; 4.2.1.20)
AO353_10705 -2.4
AO353_10710 -2.7
AO353_11175 N.D.
AO353_14865 -0.1
indole + L-serine→L-tryptophan + H2O (EC 4.2.1.122; 4.2.1.20)
AO353_10705 -2.4
AO353_10710 -2.7
AO353_11175 N.D.
AO353_14865 -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information