MetaCyc Pathway: L-valine biosynthesis in Klebsiella michiganensis M5al

Add experiment(s):


Reactions and Genes acetate (C)
remove
Acetolactate synthase:
2 pyruvate + H+→(S)-2-acetolactate + CO2 (EC 2.2.1.6)
BWI76_RS00960 -0.2
BWI76_RS00965 -4.4
BWI76_RS04695 +0.1
BWI76_RS04700 -0.4
BWI76_RS12900 -0.1
BWI76_RS16750 +0.1
BWI76_RS27810 -0.7
BWI76_RS27815 -1.4
Ketol-acid reductoisomerase (in reverse):
(S)-2-acetolactate + NADPH + H+→(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+ (EC 1.1.1.86)
BWI76_RS00990 -4.1
Dihydroxy-acid dehydratase:
(2R)-2,3-dihydroxy-3-methylbutanoate→3-methyl-2-oxobutanoate + H2O (EC 4.2.1.9)
BWI76_RS00975 -3.9
Branched-chain-amino-acid transaminase (in reverse):
3-methyl-2-oxobutanoate + L-glutamate→L-valine + 2-oxoglutarate (EC 2.6.1.42)
BWI76_RS00970 -0.9
BWI76_RS10365 +0.3
BWI76_RS24235 -0.2

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information