MetaCyc Pathway: L-tyrosine degradation I in Pseudomonas fluorescens FW300-N1B4

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Reactions and Genes L-Leucine (N)
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Aspartate transaminase:
L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
Pf1N1B4_1065 -0.5
Pf1N1B4_160 -0.2
Pf1N1B4_2018 +0.1
Pf1N1B4_2139 -0.1
Pf1N1B4_261 +0.0
Pf1N1B4_27 -1.0
Pf1N1B4_349 -0.8
Pf1N1B4_3564 +0.3
Pf1N1B4_3771 -0.4
Pf1N1B4_386 +1.3
Pf1N1B4_4186 -0.2
Pf1N1B4_4425 +0.3
Pf1N1B4_4646 +0.1
Pf1N1B4_4672 N.D.
Pf1N1B4_4996 -0.1
Pf1N1B4_5070 +0.0
Pf1N1B4_510 +0.0
Pf1N1B4_5999 +0.0
Pf1N1B4_818 -0.2
Pf1N1B4_849 -0.1
4-hydroxyphenylpyruvate dioxygenase:
3-(4-hydroxyphenyl)pyruvate + dioxygen→homogentisate + CO2 (EC 1.13.11.27)
Pf1N1B4_2747 +0.1
Pf1N1B4_5003 -0.3
Homogentisate 1,2-dioxygenase:
homogentisate + dioxygen→4-maleyl-acetoacetate + H+ (EC 1.13.11.5)
Pf1N1B4_1025 +0.1
Maleylacetoacetate isomerase:
4-maleyl-acetoacetate→4-fumaryl-acetoacetate (EC 5.2.1.2)
Pf1N1B4_1023 -0.1
Fumarylacetoacetase:
4-fumaryl-acetoacetate + H2O→acetoacetate + fumarate + H+ (EC 3.7.1.2)
Pf1N1B4_1024 -0.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information