| Reactions and Genes | L-Leucine (N) |
|---|
| remove |
3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54) |
| Pf1N1B4_269 | -0.3 |
| Pf1N1B4_289 | -0.0 |
| Pf1N1B4_5622 | -0.9 |
Holo-[acyl-carrier-protein] synthase:
an apo-[2,3-dihydroxybenzoyl-carrier protein] + coenzyme A→a holo-[2,3-dihydroxybenzoyl-carrier protein] + adenosine 3',5'-bisphosphate + H+ (EC 2.7.8.7) |
| Pf1N1B4_3480 | N.D. |
Serine--tRNA ligase:
L-serine + ATP + H+→(L-seryl)adenylate + diphosphate (EC 6.1.1.11; 6.1.1.3; 6.1.1.7; 6.2.1.72; 6.3.2.14) |
| Pf1N1B4_1984 | -0.0 |
| Pf1N1B4_3450 | N.D. |
| Pf1N1B4_4064 | N.D. |
| Pf1N1B4_6023 | N.D. |
Dimethylallyltranstransferase:
prenyl diphosphate + 3-methylbut-3-en-1-yl diphosphate→geranyl diphosphate + diphosphate (EC 2.5.1.1) |
| Pf1N1B4_2662 | N.D. |
GTP cyclohydrolase I:
GTP + H2O→7,8-dihydroneopterin 3'-triphosphate + formate + H+ (EC 3.5.4.16) |
| Pf1N1B4_1041 | +0.0 |
| Pf1N1B4_1990 | -0.0 |
| Pf1N1B4_3773 | N.D. |
Holo-[acyl-carrier-protein] synthase:
an apo-[EntF L-seryl-carrier protein] + coenzyme A→a holo-[EntF L-seryl-carrier protein] + adenosine 3',5'-bisphosphate + H+ (EC 2.7.8.7) |
| Pf1N1B4_3480 | N.D. |
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4) |
| Pf1N1B4_1537 | N.D. |
Geranyltranstransferase:
geranyl diphosphate + 3-methylbut-3-en-1-yl diphosphate→(2E,6E)-farnesyl diphosphate + diphosphate (EC 2.5.1.10) |
| Pf1N1B4_2662 | N.D. |
| 7,8-dihydroneopterin 3'-triphosphate + H2O→7,8-dihydroneopterin 3'-phosphate + diphosphate + H+ (EC 3.6.1.67) |
| No genes |
| a holo-[EntF L-seryl-carrier protein] + (L-seryl)adenylate→a seryl-[EntF L-seryl-carrier protein] + AMP + H+ (EC 6.2.1.72; 6.3.2.14) |
| No genes |
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10) |
| Pf1N1B4_1307 | -1.8 |
| Pf1N1B4_2750 | -0.1 |
| Pf1N1B4_3104 | N.D. |
| 7,8-dihydroneopterin 3'-phosphate + H2O→D-erythro-7,8-dihydroneopterin + phosphate |
| No genes |
| (2E,6E)-farnesyl diphosphate + 5 3-methylbut-3-en-1-yl diphosphate→all-trans-octaprenyl diphosphate + 5 diphosphate (EC 2.5.1.90) |
| Pf1N1B4_2662 | N.D. |
| Pf1N1B4_2796 | N.D. |
Dihydroneopterin aldolase:
D-erythro-7,8-dihydroneopterin→6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde (EC 4.1.2.25) |
| Pf1N1B4_2518 | N.D. |
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25) |
| Pf1N1B4_1906 | -2.0 |
| Pf1N1B4_2749 | -0.1 |
| Pf1N1B4_3930 | -0.3 |
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase:
6-(hydroxymethyl)-7,8-dihydropterin + ATP→(7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H+ (EC 2.7.6.3) |
| Pf1N1B4_2519 | N.D. |
| Pf1N1B4_2855 | N.D. |
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71) |
| Pf1N1B4_1538 | N.D. |
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19) |
| Pf1N1B4_348 | -0.5 |
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5) |
| Pf1N1B4_3780 | N.D. |
Anthranilate synthase:
chorismate + L-glutamine→anthranilate + L-glutamate + H+ + pyruvate (EC 4.1.3.27) |
| Pf1N1B4_2545 | -2.8 |
| Pf1N1B4_2547 | -3.1 |
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5) |
| Pf1N1B4_350 | -3.0 |
Chorismate lyase:
chorismate→4-hydroxybenzoate + pyruvate (EC 4.1.3.40) |
| Pf1N1B4_1214 | +0.2 |
| Pf1N1B4_2047 | +0.2 |
Isochorismate synthase:
chorismate→isochorismate (EC 5.4.4.2) |
| No genes |
Aminodeoxychorismate synthase:
chorismate + L-glutamine→4-amino-4-deoxychorismate + L-glutamate (EC 2.6.1.85) |
| Pf1N1B4_2547 | -3.1 |
| Pf1N1B4_3797 | -0.2 |
| Pf1N1B4_3814 | -0.1 |
synthase:
isochorismate + 2-oxoglutarate + H+→(1R,2S,5S,6S)-2-succinyl-5-enolpyruvyl-6-hydroxycyclohex-3-ene-1-carboxylate + CO2 (EC 2.2.1.9) |
| No genes |
4-hydroxybenzoate nonaprenyltransferase:
4-hydroxybenzoate + all-trans-octaprenyl diphosphate→4-hydroxy-3-octaprenylbenzoate + diphosphate (EC 2.5.1.39) |
| Pf1N1B4_2046 | N.D. |
Aminodeoxychorismate lyase:
4-amino-4-deoxychorismate→4-aminobenzoate + H+ + pyruvate (EC 4.1.3.38) |
| Pf1N1B4_448 | +0.2 |
Isochorismatase:
isochorismate + H2O→(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate (EC 3.3.2.1) |
| Pf1N1B4_2623 | -0.0 |
| Pf1N1B4_3184 | +0.5 |
| Pf1N1B4_3776 | N.D. |
| Pf1N1B4_4083 | -0.1 |
Prephenate dehydratase:
prephenate + H+→3-phenyl-2-oxopropanoate + CO2 + H2O (EC 4.2.1.51) |
| Pf1N1B4_350 | -3.0 |
| Pf1N1B4_54 | +0.7 |
Prephenate dehydrogenase:
prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12) |
| Pf1N1B4_348 | -0.5 |
Anthranilate phosphoribosyltransferase (in reverse):
anthranilate + 5-phospho-α-D-ribose 1-diphosphate→N-(5-phosphoribosyl)-anthranilate + diphosphate (EC 2.4.2.18) |
| Pf1N1B4_2548 | -2.8 |
| Pf1N1B4_4067 | +0.2 |
| 4-hydroxy-3-octaprenylbenzoate + H+→2-octaprenylphenol + CO2 (EC 4.1.1.98) |
| Pf1N1B4_2217 | N.D. |
| Pf1N1B4_2677 | N.D. |
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase:
(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD+→2,3-dihydroxybenzoate + NADH + H+ (EC 1.3.1.28) |
| No genes |
Dihydropteroate synthase:
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate→7,8-dihydropteroate + diphosphate (EC 2.5.1.15) |
| Pf1N1B4_1166 | N.D. |
Phosphoribosylanthranilate isomerase:
N-(5-phosphoribosyl)-anthranilate→1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (EC 5.3.1.24) |
| Pf1N1B4_5 | N.D. |
| Pf1N1B4_6 | -4.0 |
Aspartate transaminase (in reverse):
3-phenyl-2-oxopropanoate + L-glutamate→L-phenylalanine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57) |
| Pf1N1B4_1065 | -0.5 |
| Pf1N1B4_160 | -0.2 |
| Pf1N1B4_2018 | +0.1 |
| Pf1N1B4_2139 | -0.1 |
| Pf1N1B4_261 | +0.0 |
| Pf1N1B4_27 | -1.0 |
| Pf1N1B4_349 | -0.8 |
| Pf1N1B4_3564 | +0.3 |
| Pf1N1B4_3771 | -0.4 |
| Pf1N1B4_386 | +1.3 |
| Pf1N1B4_4186 | -0.2 |
| Pf1N1B4_4425 | +0.3 |
| Pf1N1B4_4646 | +0.1 |
| Pf1N1B4_4672 | N.D. |
| Pf1N1B4_4996 | -0.1 |
| Pf1N1B4_5070 | +0.0 |
| Pf1N1B4_510 | +0.0 |
| Pf1N1B4_5999 | +0.0 |
| Pf1N1B4_818 | -0.2 |
| Pf1N1B4_849 | -0.1 |
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase:
(1R,2S,5S,6S)-2-succinyl-5-enolpyruvyl-6-hydroxycyclohex-3-ene-1-carboxylate→(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate (EC 4.2.99.20) |
| No genes |
Aspartate transaminase (in reverse):
3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57) |
| Pf1N1B4_1065 | -0.5 |
| Pf1N1B4_160 | -0.2 |
| Pf1N1B4_2018 | +0.1 |
| Pf1N1B4_2139 | -0.1 |
| Pf1N1B4_261 | +0.0 |
| Pf1N1B4_27 | -1.0 |
| Pf1N1B4_349 | -0.8 |
| Pf1N1B4_3564 | +0.3 |
| Pf1N1B4_3771 | -0.4 |
| Pf1N1B4_386 | +1.3 |
| Pf1N1B4_4186 | -0.2 |
| Pf1N1B4_4425 | +0.3 |
| Pf1N1B4_4646 | +0.1 |
| Pf1N1B4_4672 | N.D. |
| Pf1N1B4_4996 | -0.1 |
| Pf1N1B4_5070 | +0.0 |
| Pf1N1B4_510 | +0.0 |
| Pf1N1B4_5999 | +0.0 |
| Pf1N1B4_818 | -0.2 |
| Pf1N1B4_849 | -0.1 |
| 2-octaprenylphenol + NADPH + dioxygen + H+→3-(all-trans-octaprenyl)benzene-1,2-diol + NADP+ + H2O (EC 1.14.13.240) |
| Pf1N1B4_1564 | N.D. |
| Pf1N1B4_2231 | N.D. |
| 2,3-dihydroxybenzoate + ATP + H+→(2,3-dihydroxybenzoyl)adenylate + diphosphate (EC 6.2.1.71) |
| No genes |
Dihydrofolate synthase:
7,8-dihydropteroate + ATP + L-glutamate→7,8-dihydrofolate monoglutamate + ADP + H+ + phosphate (EC 6.3.2.12) |
| Pf1N1B4_3 | N.D. |
Indole-3-glycerol-phosphate synthase:
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+→(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O (EC 4.1.1.48) |
| Pf1N1B4_2549 | -2.8 |
o-succinylbenzoate synthase:
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate→2-succinylbenzoate + H2O (EC 4.2.1.113) |
| No genes |
| 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine→2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.222) |
| Pf1N1B4_356 | N.D. |
Dihydrofolate reductase (in reverse):
a 7,8-dihydrofolate + NADPH + H+→a tetrahydrofolate + NADP+ (EC 1.5.1.3) |
| Pf1N1B4_1040 | +0.2 |
| Pf1N1B4_2300 | N.D. |
o-succinylbenzoate--CoA ligase:
2-succinylbenzoate + ATP + coenzyme A→4-(2'-carboxyphenyl)-4-oxobutyryl-CoA + AMP + diphosphate (EC 6.2.1.26) |
| No genes |
Indole-3-glycerol-phosphate lyase:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate→indole + D-glyceraldehyde 3-phosphate (EC 4.1.2.8; 4.2.1.20) |
| Pf1N1B4_1118 | +0.2 |
| Pf1N1B4_1800 | N.D. |
| Pf1N1B4_1830 | -2.8 |
| Pf1N1B4_1831 | -3.0 |
| (2,3-dihydroxybenzoyl)adenylate + a holo-[2,3-dihydroxybenzoyl-carrier protein]→a 2,3-dihydroxybenzoyl-[2,3-dihydroxybenzoyl-carrier protein] + AMP + H+ (EC 6.2.1.71) |
| No genes |
| 2-methoxy-6-(all-trans-octaprenyl)phenol + NADPH + dioxygen + H+→2-methoxy-6-all trans-octaprenyl-1,4-benzoquinol + NADP+ + H2O (EC 1.14.13.M56) |
| No genes |
Naphthoate synthase:
4-(2'-carboxyphenyl)-4-oxobutyryl-CoA + H+→1,4-dihydroxy-2-naphthoyl-CoA + H2O (EC 4.1.3.36) |
| No genes |
2,3-dihydroxybenzoate--serine ligase:
a 2,3-dihydroxybenzoyl-[2,3-dihydroxybenzoyl-carrier protein] + a seryl-[EntF L-seryl-carrier protein]→a holo-[2,3-dihydroxybenzoyl-carrier protein] + an N-(2,3-dihydroxybenzoyl)-seryl-[EntF L-seryl-carrier protein] + H+ (EC 6.3.2.14) |
| No genes |
| indole + L-serine→L-tryptophan + H2O (EC 4.2.1.122; 4.2.1.20) |
| Pf1N1B4_1118 | +0.2 |
| Pf1N1B4_1800 | N.D. |
| Pf1N1B4_1830 | -2.8 |
| Pf1N1B4_1831 | -3.0 |
| 2-methoxy-6-all trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine→6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.201) |
| Pf1N1B4_1562 | N.D. |
2,3-dihydroxybenzoate--serine ligase:
3 an N-(2,3-dihydroxybenzoyl)-seryl-[EntF L-seryl-carrier protein]→3 a holo-[EntF L-seryl-carrier protein] + enterobactin (EC 6.3.2.14) |
| No genes |
| 1,4-dihydroxy-2-naphthoyl-CoA + H2O→1,4-dihydroxy-2-naphthoate + coenzyme A + H+ (EC 3.1.2.28) |
| Pf1N1B4_3522 | N.D. |
| 1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H+→demethylmenaquinol-8 + CO2 + diphosphate (EC 2.5.1.74) |
| No genes |
| 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + a reduced two electron carrier + dioxygen→3-demethylubiquinol-8 + an oxidized electron carrier + H2O (EC 1.14.99.60) |
| No genes |
| demethylmenaquinol-8 + S-adenosyl-L-methionine→menaquinol-8 + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.163) |
| Pf1N1B4_1562 | N.D. |
3-demethylubiquinone-9 3-O-methyltransferase:
3-demethylubiquinol-8 + S-adenosyl-L-methionine→ubiquinol-8 + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.64) |
| Pf1N1B4_1289 | -0.3 |
| Pf1N1B4_356 | N.D. |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information