MetaCyc Pathway: methyl tert-butyl ether degradation in Acidovorax sp. GW101-3H11

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Reactions and Genes L-Isoleucine (N)
remove
methyl tert-butyl ether + NADH + dioxygen + H+→tert-butoxymethanol + NAD+ + H2O (EC 1.14.13.M36)
No genes
tert-butoxymethanol + NAD+→tert-butyl formate + NADH + H+ (EC 1.1.1.M26)
No genes
tert-butyl formate + H2O→tert-butyl alcohol + formate + H+
No genes
tert-butyl alcohol + NADPH + dioxygen + H+→2-methylpropane-1,2-diol + NADP+ + H2O (EC 1.14.13.229)
No genes
2-methylpropane-1,2-diol + NAD+→2-hydroxy-2-methylpropanal + NADH + H+ (EC 1.1.1.400)
No genes
2-hydroxy-2-methylpropanal + NAD+ + H2O→2-hydroxy-2-methylpropanoate + NADH + 2 H+ (EC 1.2.1.98)
No genes
2-hydroxy-2-methylpropanoate + ATP + coenzyme A→2-hydroxy-2-methylpropanoyl-CoA + AMP + diphosphate (EC 6.2.1.M4)
No genes
2-hydroxy-2-methylpropanoyl-CoA→(S)-3-hydroxybutanoyl-CoA (EC 5.4.99.64)
No genes
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD+→acetoacetyl-CoA + NADH + H+ (EC 1.1.1.35)
Ac3H11_1056 N.D.
Ac3H11_1914 -0.2
Ac3H11_1931 -0.1
Ac3H11_2523 -0.2
Ac3H11_2606 -5.2
Ac3H11_2741 -0.3
Ac3H11_4075 -0.1
Ac3H11_4658 -0.2
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
Ac3H11_178 -0.0
Ac3H11_1916 -0.1
Ac3H11_1932 +0.0
Ac3H11_2303 -0.3
Ac3H11_2522 +0.2
Ac3H11_2740 N.D.
Ac3H11_2769 -0.4
Ac3H11_2994 -3.0
Ac3H11_3407 +0.3
Ac3H11_3408 +0.1
Ac3H11_3920 -0.6

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information