MetaCyc Pathway: L-citrulline biosynthesis in Acidovorax sp. GW101-3H11

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Reactions and Genes L-Proline (N)
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Arginase:
L-arginine + H2O→L-ornithine + urea (EC 3.5.3.1)
Ac3H11_701 +0.2
Glutamate synthase (NADPH):
L-glutamine + H2O→L-glutamate + ammonia + H+ (EC 1.4.1.13; 1.4.1.14; 1.4.7.1; 2.6.1.85; 3.5.1.2; 3.5.1.38; 4.1.3.27; 4.3.2.10; 4.3.3.6; 6.3.4.2; 6.3.5.13; 6.3.5.2; 6.3.5.4; 6.3.5.5; 6.3.5.6; 6.3.5.7)
Ac3H11_1167 -0.1
Ac3H11_1552 +0.2
Ac3H11_1824 +0.3
Ac3H11_1866 +0.1
Ac3H11_2500 -0.1
Ac3H11_2508 -0.1
Ac3H11_2854 N.D.
Ac3H11_288 N.D.
Ac3H11_2953 +0.0
Ac3H11_3337 N.D.
Ac3H11_3338 N.D.
Ac3H11_3339 N.D.
Ac3H11_3836 -0.3
Ac3H11_435 N.D.
Ac3H11_4354 +0.1
Ac3H11_436 N.D.
Ac3H11_4710 -1.4
Ac3H11_4711 -1.5
Ac3H11_4821 +0.3
Ac3H11_734 -0.1
Ac3H11_767 -6.1
Ac3H11_769 -5.9
L-proline[in] + an electron-transfer quinone→(S)-1-pyrroline-5-carboxylate[in] + an electron-transfer quinol + H+[in] (EC 1.5.5.2)
Ac3H11_2850 -5.6
Glutamate 5-kinase:
L-glutamate + ATP→γ-L-glutamyl 5-phosphate + ADP (EC 2.7.2.11)
Ac3H11_4771 +0.4
(S)-1-pyrroline-5-carboxylate + H+ + H2O→L-glutamate 5-semialdehyde (spontaneous)
No genes
Glutamate-5-semialdehyde dehydrogenase (in reverse):
γ-L-glutamyl 5-phosphate + NADPH + H+→L-glutamate 5-semialdehyde + NADP+ + phosphate (EC 1.2.1.41)
Ac3H11_704 +0.0
Ornithine aminotransferase (in reverse):
L-glutamate + L-glutamate 5-semialdehyde→L-ornithine + 2-oxoglutarate (EC 2.6.1.13)
No genes
Ornithine carbamoyltransferase:
L-ornithine + carbamoyl phosphate→L-citrulline + H+ + phosphate (EC 2.1.3.3)
Ac3H11_1333 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information