MetaCyc Pathway: superpathway of menaquinol-10 biosynthesis in Shewanella sp. ANA-3

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Reactions and Genes Anaero. fumarate as e acceptor
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Isochorismate synthase:
chorismate→isochorismate
(EC 5.4.4.2)
Shewana3_4071 -2.0
(2E,6E)-farnesyl diphosphate + 7 3-methylbut-3-en-1-yl diphosphate→all-trans-decaprenyl diphosphate + 7 diphosphate (EC 2.5.1.91)
No genes
synthase:
isochorismate + 2-oxoglutarate + H+→(1R,2S,5S,6S)-2-succinyl-5-enolpyruvyl-6-hydroxycyclohex-3-ene-1-carboxylate + CO2
(EC 2.2.1.9)
Shewana3_3965 -2.2
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase:
(1R,2S,5S,6S)-2-succinyl-5-enolpyruvyl-6-hydroxycyclohex-3-ene-1-carboxylate→(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate
(EC 4.2.99.20)
Shewana3_3966 -1.7
o-succinylbenzoate synthase:
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate→2-succinylbenzoate + H2O
(EC 4.2.1.113)
Shewana3_3967 -2.0
o-succinylbenzoate--CoA ligase:
2-succinylbenzoate + ATP + coenzyme A→4-(2'-carboxyphenyl)-4-oxobutyryl-CoA + AMP + diphosphate
(EC 6.2.1.26)
Shewana3_3968 -2.6
Naphthoate synthase:
4-(2'-carboxyphenyl)-4-oxobutyryl-CoA + H+→1,4-dihydroxy-2-naphthoyl-CoA + H2O
(EC 4.1.3.36)
Shewana3_4123 -2.3
1,4-dihydroxy-2-naphthoyl-CoA + H2O→1,4-dihydroxy-2-naphthoate + coenzyme A + H+ (EC 3.1.2.28)
Shewana3_0085 +0.1
Shewana3_0906 +0.2
all-trans-decaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H+→demethylmenaquinol-10 + CO2 + diphosphate (EC 2.5.1.74)
Shewana3_1686 -1.8
demethylmenaquinol-10 + S-adenosyl-L-methionine→menaquinol-10 + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.163)
Shewana3_3725 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information