MetaCyc Pathway: γ-glutamyl cycle in Acidovorax sp. GW101-3H11

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Reactions and Genes L-Glutamine (N)
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5-oxoprolinase (ATP-hydrolyzing):
5-oxo-L-proline + ATP + 2 H2O→L-glutamate + ADP + H+ + phosphate (EC 3.5.2.9)
Ac3H11_153 -1.9
Ac3H11_2588 +0.1
Glutamate--cysteine ligase:
L-glutamate + L-cysteine + ATP→γ-L-glutamyl-L-cysteine + ADP + H+ + phosphate (EC 6.3.2.2)
Ac3H11_3126 -0.4
Ac3H11_708 +0.0
Ac3H11_753 N.D.
Glutathione synthase:
γ-L-glutamyl-L-cysteine + ATP + glycine→glutathione + ADP + H+ + phosphate (EC 6.3.2.3)
Ac3H11_711 -1.1
Gamma-glutamyltransferase:
glutathione + a proteinogenic amino acid→an α-(γ-L-glutamyl)-L-amino acid + L-cysteinylglycine (EC 2.3.2.2)
Ac3H11_1090 -0.0
Ac3H11_4929 -0.1
Ac3H11_7 -0.2
Ac3H11_776 +0.2
an α-(γ-L-glutamyl)-L-amino acid→5-oxo-L-proline + an L-amino acid (EC 4.3.2.9)
No genes
Cytosol nonspecific dipeptidase:
L-cysteinylglycine + H2O→L-cysteine + glycine (EC 3.4.13.18)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information