MetaCyc Pathway: superpathway of guanosine nucleotides de novo biosynthesis I in Pseudomonas fluorescens FW300-N2E3

Reactions and Genes	acetate 17 mM
IMP dehydrogenase: IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)
AO353_15950	N.D.
AO353_25270	-0.1
AO353_29360	-0.1
GMP synthase (glutamine-hydrolyzing): XMP + ATP + L-glutamine + H2O→GMP + AMP + L-glutamate + diphosphate + 2 H+ (EC 6.3.5.2)
AO353_10550	+1.7
AO353_15955	N.D.
Guanylate kinase: GMP + ATP→GDP + ADP (EC 2.7.4.8)
AO353_02935	+0.2
AO353_09270	N.D.
Nucleoside-diphosphate kinase: GDP + ATP→GTP + ADP (EC 2.7.4.6)
AO353_15870	N.D.
AO353_16315	N.D.
Ribonucleoside-diphosphate reductase (in reverse): GDP + a reduced thioredoxin→dGDP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
AO353_02840	N.D.
AO353_03070	N.D.
Nucleoside-diphosphate kinase: dGDP + ATP→dGTP + ADP (EC 2.7.4.6)
AO353_15870	N.D.
AO353_16315	N.D.

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information