MetaCyc Pathway: noradrenaline and adrenaline degradation in Pseudomonas fluorescens FW300-N2E3

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Reactions and Genes Furfuryl Alcohol 0.25 vol%
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Catechol O-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→L-normetanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
(R)-noradrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
Phenylethanolamine N-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→(R)-adrenaline + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.28)
No genes
Monoamine oxidase:
(R)-adrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
No genes
Catechol O-methyltransferase:
(R)-adrenaline + S-adenosyl-L-methionine→metanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
L-normetanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
Alcohol dehydrogenase (in reverse):
3,4-dihydroxyphenylglycolaldehyde + NADH + H+→(R)-3,4-dihydroxyphenylglycol + NAD+ (EC 1.1.1.1)
AO353_01250 -0.1
AO353_07245 -0.0
AO353_16580 -1.2
AO353_17425 -0.1
AO353_19865 +0.0
AO353_22415 -0.2
AO353_24900 +0.3
AO353_28025 +0.0
Aldehyde dehydrogenase (NAD(+)):
3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O→3,4-dihydroxymandelate + NADH + 2 H+ (EC 1.2.1.3)
AO353_03860 -0.0
AO353_05300 +0.0
AO353_06560 +0.2
AO353_08290 +0.1
AO353_09195 -0.0
AO353_13330 -0.2
AO353_15035 +0.3
AO353_19510 +0.0
AO353_22390 +0.2
AO353_23135 +0.1
AO353_24855 -0.1
AO353_24905 -0.1
AO353_28290 -0.5
Monoamine oxidase:
metanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
No genes
Catechol O-methyltransferase:
(R)-3,4-dihydroxyphenylglycol + S-adenosyl-L-methionine→3-methoxy-4-hydroxyphenylglycol + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Catechol O-methyltransferase:
3,4-dihydroxymandelate + S-adenosyl-L-methionine→vanillylmandelate + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Alcohol dehydrogenase:
3-methoxy-4-hydroxyphenylglycol + NAD+→3-methoxy-4-hydroxyphenylglycolaldehyde + NADH + H+ (EC 1.1.1.1)
AO353_01250 -0.1
AO353_07245 -0.0
AO353_16580 -1.2
AO353_17425 -0.1
AO353_19865 +0.0
AO353_22415 -0.2
AO353_24900 +0.3
AO353_28025 +0.0
Aldehyde dehydrogenase (NAD(+)):
3-methoxy-4-hydroxyphenylglycolaldehyde + NAD+ + H2O→vanillylmandelate + NADH + 2 H+ (EC 1.2.1.3)
AO353_03860 -0.0
AO353_05300 +0.0
AO353_06560 +0.2
AO353_08290 +0.1
AO353_09195 -0.0
AO353_13330 -0.2
AO353_15035 +0.3
AO353_19510 +0.0
AO353_22390 +0.2
AO353_23135 +0.1
AO353_24855 -0.1
AO353_24905 -0.1
AO353_28290 -0.5

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information