MetaCyc Pathway: valproate β-oxidation in Sphingomonas koreensis DSMZ 15582

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Reactions and Genes Vanillin 0.25 mM
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Butyrate--CoA ligase:
valproate + ATP + coenzyme A→valproyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
valproyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-2-propylpent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-2-propylpent-2-enoyl-CoA + H2O→(3S)-3-hydroxy-2-propylpentanoyl-CoA (EC 4.2.1.17)
Ga0059261_0515 +0.2
Ga0059261_0837 -0.1
Ga0059261_2159 -0.4
Ga0059261_2668 -0.0
Ga0059261_2803 +0.0
Ga0059261_2815 +0.0
Ga0059261_2818 +0.1
Ga0059261_2827 -0.1
Ga0059261_2840 +0.1
Ga0059261_2847 -0.2
Ga0059261_2858 -0.0
Ga0059261_2861 +0.0
Ga0059261_2887 +0.0
Ga0059261_2902 -0.1
Ga0059261_2908 +0.0
Ga0059261_3683 -1.2
Ga0059261_3685 -2.4
Ga0059261_3986 +0.1
Ga0059261_4214 -0.8
Ga0059261_4222 -0.1
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxy-2-propylpentanoyl-CoA + NAD+→3-oxo-2-propylpentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
Ga0059261_0837 -0.1
Ga0059261_2534 -0.7
Ga0059261_2816 +0.1
Ga0059261_2827 -0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-2-propylpentanoyl-CoA + coenzyme A→pentanoyl-CoA + propanoyl-CoA (EC 2.3.1.16)
Ga0059261_0982 -0.3
Ga0059261_1483 -0.4
Ga0059261_2108 -0.0
Ga0059261_2160 +0.0
Ga0059261_2808 -0.1
Ga0059261_2835 -0.0
Ga0059261_2867 +0.0
Ga0059261_2877 +0.1
Ga0059261_2888 +0.1
Ga0059261_3284 -0.4
pentanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-pent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
Ga0059261_3681 -0.2
(2E)-pent-2-enoyl-CoA + H2O→(3S)-3-hydroxypentanoyl-CoA
No genes
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxypentanoyl-CoA + NAD+→3-oxopentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
Ga0059261_0837 -0.1
Ga0059261_2534 -0.7
Ga0059261_2816 +0.1
Ga0059261_2827 -0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxopentanoyl-CoA + coenzyme A→propanoyl-CoA + acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
Ga0059261_0982 -0.3
Ga0059261_1483 -0.4
Ga0059261_2108 -0.0
Ga0059261_2160 +0.0
Ga0059261_2808 -0.1
Ga0059261_2835 -0.0
Ga0059261_2867 +0.0
Ga0059261_2877 +0.1
Ga0059261_2888 +0.1
Ga0059261_3284 -0.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information