MetaCyc Pathway: siroheme biosynthesis in Pantoea sp. MT58

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Reactions and Genes nitrogen source nitrate 5mM
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Uroporphyrinogen-III C-methyltransferase:
uroporphyrinogen-III + S-adenosyl-L-methionine→precorrin-1 + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.107)
IAI47_04175 -2.2
IAI47_11160 -2.4
IAI47_18435 +0.6
Uroporphyrinogen-III C-methyltransferase:
precorrin-1 + S-adenosyl-L-methionine→precorrin-2 + S-adenosyl-L-homocysteine (EC 2.1.1.107)
IAI47_04175 -2.2
IAI47_11160 -2.4
IAI47_18435 +0.6
Precorrin-2 dehydrogenase:
precorrin-2 + NAD+→sirohydrochlorin + NADH + 2 H+ (EC 1.3.1.76)
IAI47_04175 -2.2
IAI47_11160 -2.4
Sirohydrochlorin ferrochelatase:
sirohydrochlorin + Fe2+→siroheme + 2 H+ (EC 4.99.1.4)
IAI47_04175 -2.2
IAI47_11160 -2.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information