MetaCyc Pathway: 2-methyl-branched fatty acid β-oxidation in Sphingomonas koreensis DSMZ 15582

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Reactions and Genes Gentamicin 0.015 mg/ml
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Butyrate--CoA ligase:
a short-chain 2-methyl-branched fatty acid + ATP + coenzyme A→a short-chain 2-methyl fatty acyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
a long-chain 2-methyl fatty acyl-CoA + an oxidized electron-transfer flavoprotein + H+→a long-chain (2E)-2-methyl-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.8)
No genes
Butyrate--CoA ligase:
a medium-chain 2-methyl-branched fatty acid + ATP + coenzyme A→a medium-chain 2-methyl fatty acyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
a short-chain 2-methyl fatty acyl-CoA + an oxidized electron-transfer flavoprotein + H+→a short-chain (2E)-2-methyl-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
a medium-chain 2-methyl fatty acyl-CoA + an oxidized electron-transfer flavoprotein + H+→a medium-chain (2E)-2-methyl-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
Ga0059261_0740 -0.1
Ga0059261_0847 +0.0
Ga0059261_1309 +0.1
Ga0059261_3633 -0.2
Enoyl-CoA hydratase (in reverse):
a long-chain (2E)-2-methyl-2-enoyl-CoA + H2O→a long-chain (3S)-3-hydroxy-2-methylacyl-CoA (EC 4.2.1.17)
Ga0059261_0515 -0.0
Ga0059261_0837 -0.1
Ga0059261_2159 -0.1
Ga0059261_2668 +0.1
Ga0059261_2803 +0.1
Ga0059261_2815 +0.1
Ga0059261_2818 +0.1
Ga0059261_2827 +0.0
Ga0059261_2840 -0.3
Ga0059261_2847 -0.2
Ga0059261_2858 +0.0
Ga0059261_2861 -0.0
Ga0059261_2887 -0.1
Ga0059261_2902 -0.1
Ga0059261_2908 +0.1
Ga0059261_3683 -0.1
Ga0059261_3685 -0.4
Ga0059261_3986 +0.2
Ga0059261_4214 -0.5
Ga0059261_4222 -0.0
Enoyl-CoA hydratase (in reverse):
a short-chain (2E)-2-methyl-2-enoyl-CoA + H2O→a short-chain (3S)-3-hydroxy-2-methylacyl-CoA (EC 4.2.1.17)
Ga0059261_0515 -0.0
Ga0059261_0837 -0.1
Ga0059261_2159 -0.1
Ga0059261_2668 +0.1
Ga0059261_2803 +0.1
Ga0059261_2815 +0.1
Ga0059261_2818 +0.1
Ga0059261_2827 +0.0
Ga0059261_2840 -0.3
Ga0059261_2847 -0.2
Ga0059261_2858 +0.0
Ga0059261_2861 -0.0
Ga0059261_2887 -0.1
Ga0059261_2902 -0.1
Ga0059261_2908 +0.1
Ga0059261_3683 -0.1
Ga0059261_3685 -0.4
Ga0059261_3986 +0.2
Ga0059261_4214 -0.5
Ga0059261_4222 -0.0
Enoyl-CoA hydratase (in reverse):
a medium-chain (2E)-2-methyl-2-enoyl-CoA + H2O→a medium-chain (3S)-3-hydroxy-2-methylacyl-CoA (EC 4.2.1.17)
Ga0059261_0515 -0.0
Ga0059261_0837 -0.1
Ga0059261_2159 -0.1
Ga0059261_2668 +0.1
Ga0059261_2803 +0.1
Ga0059261_2815 +0.1
Ga0059261_2818 +0.1
Ga0059261_2827 +0.0
Ga0059261_2840 -0.3
Ga0059261_2847 -0.2
Ga0059261_2858 +0.0
Ga0059261_2861 -0.0
Ga0059261_2887 -0.1
Ga0059261_2902 -0.1
Ga0059261_2908 +0.1
Ga0059261_3683 -0.1
Ga0059261_3685 -0.4
Ga0059261_3986 +0.2
Ga0059261_4214 -0.5
Ga0059261_4222 -0.0
3-hydroxyacyl-CoA dehydrogenase:
a long-chain (3S)-3-hydroxy-2-methylacyl-CoA + NAD+→a long-chain 2-methyl-3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.35)
Ga0059261_0837 -0.1
Ga0059261_2534 -0.6
Ga0059261_2816 -0.0
Ga0059261_2827 +0.0
3-hydroxy-2-methylbutyryl-CoA dehydrogenase:
a short-chain (3S)-3-hydroxy-2-methylacyl-CoA + NAD+→a short-chain 2-methyl-3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.178)
No genes
3-hydroxyacyl-CoA dehydrogenase:
a medium-chain (3S)-3-hydroxy-2-methylacyl-CoA + NAD+→a medium-chain 2-methyl-3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.35)
Ga0059261_0837 -0.1
Ga0059261_2534 -0.6
Ga0059261_2816 -0.0
Ga0059261_2827 +0.0
Acetyl-CoA C-acyltransferase (in reverse):
a long-chain 2-methyl-3-oxoacyl-CoA + coenzyme A→a long-chain 2-methyl fatty acyl-CoA + propanoyl-CoA (EC 2.3.1.16)
Ga0059261_0982 +0.0
Ga0059261_1483 -2.0
Ga0059261_2108 -0.1
Ga0059261_2160 -0.1
Ga0059261_2808 -0.1
Ga0059261_2835 +0.0
Ga0059261_2867 -0.1
Ga0059261_2877 -0.0
Ga0059261_2888 +0.0
Ga0059261_3284 -0.4
Acetyl-CoA C-acyltransferase (in reverse):
a short-chain 2-methyl-3-oxoacyl-CoA + coenzyme A→a short-chain 2-methyl fatty acyl-CoA + propanoyl-CoA (EC 2.3.1.16)
Ga0059261_0982 +0.0
Ga0059261_1483 -2.0
Ga0059261_2108 -0.1
Ga0059261_2160 -0.1
Ga0059261_2808 -0.1
Ga0059261_2835 +0.0
Ga0059261_2867 -0.1
Ga0059261_2877 -0.0
Ga0059261_2888 +0.0
Ga0059261_3284 -0.4
Acetyl-CoA C-acyltransferase (in reverse):
a medium-chain 2-methyl-3-oxoacyl-CoA + coenzyme A→a medium-chain 2-methyl fatty acyl-CoA + propanoyl-CoA (EC 2.3.1.16)
Ga0059261_0982 +0.0
Ga0059261_1483 -2.0
Ga0059261_2108 -0.1
Ga0059261_2160 -0.1
Ga0059261_2808 -0.1
Ga0059261_2835 +0.0
Ga0059261_2867 -0.1
Ga0059261_2877 -0.0
Ga0059261_2888 +0.0
Ga0059261_3284 -0.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information