MetaCyc Pathway: propanoate fermentation to 2-methylbutanoate in Sphingomonas koreensis DSMZ 15582

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Reactions and Genes Gentamicin 0.015 mg/ml
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Propionate CoA-transferase:
propanoate + acetyl-CoA→acetate + propanoyl-CoA (EC 2.8.3.1)
No genes
Acetyl-CoA C-acyltransferase:
propanoyl-CoA + acetyl-CoA→2-methylacetoacetyl-CoA + coenzyme A (EC 2.3.1.16)
Ga0059261_0982 +0.0
Ga0059261_1483 -2.0
Ga0059261_2108 -0.1
Ga0059261_2160 -0.1
Ga0059261_2808 -0.1
Ga0059261_2835 +0.0
Ga0059261_2867 -0.1
Ga0059261_2877 -0.0
Ga0059261_2888 +0.0
Ga0059261_3284 -0.4
3-hydroxy-2-methylbutyryl-CoA dehydrogenase (in reverse):
2-methylacetoacetyl-CoA + NADH + H+→(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ (EC 1.1.1.178)
Ga0059261_0837 -0.1
Ga0059261_2827 +0.0
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA→(E)-2-methylcrotonoyl-CoA + H2O (EC 4.2.1.150)
Ga0059261_0515 -0.0
Ga0059261_0837 -0.1
Ga0059261_2159 -0.1
Ga0059261_2668 +0.1
Ga0059261_2803 +0.1
Ga0059261_2815 +0.1
Ga0059261_2818 +0.1
Ga0059261_2827 +0.0
Ga0059261_2840 -0.3
Ga0059261_2847 -0.2
Ga0059261_2858 +0.0
Ga0059261_2861 -0.0
Ga0059261_2887 -0.1
Ga0059261_2902 -0.1
Ga0059261_2908 +0.1
Ga0059261_3685 -0.4
Ga0059261_3986 +0.2
Ga0059261_4214 -0.5
Ga0059261_4222 -0.0
(E)-2-methylcrotonoyl-CoA + a reduced electron-transfer flavoprotein→(2S)-2-methylbutanoyl-CoA + an oxidized electron-transfer flavoprotein + H+ (EC 1.3.8.5)
No genes
(2S)-2-methylbutanoyl-CoA + H2O→2-methylbutanoate + coenzyme A + H+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information