MetaCyc Pathway: benzoate biosynthesis I (CoA-dependent, β-oxidative) in Sphingomonas koreensis DSMZ 15582

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Reactions and Genes Gentamicin 0.005 mg/ml
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Phenylalanine ammonia-lyase:
L-phenylalanine→trans-cinnamate + ammonium (EC 4.3.1.24; 4.3.1.25; 5.4.3.10)
No genes
trans-cinnamate + ATP + coenzyme A→(E)-cinnamoyl-CoA + AMP + diphosphate
No genes
Enoyl-CoA hydratase (in reverse):
(E)-cinnamoyl-CoA + H2O→(S)-3-hydroxy-3-phenylpropanoyl-CoA (EC 4.2.1.17)
Ga0059261_0515 -0.0
Ga0059261_0837 -0.1
Ga0059261_2159 -0.1
Ga0059261_2668 +0.0
Ga0059261_2803 -0.1
Ga0059261_2815 +0.2
Ga0059261_2818 +0.1
Ga0059261_2827 -0.1
Ga0059261_2840 -0.3
Ga0059261_2847 -0.0
Ga0059261_2858 +0.2
Ga0059261_2861 +0.0
Ga0059261_2887 -0.0
Ga0059261_2902 -0.1
Ga0059261_2908 -0.0
Ga0059261_3683 -0.1
Ga0059261_3685 -0.3
Ga0059261_3986 +0.0
Ga0059261_4214 -0.1
Ga0059261_4222 +0.1
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxy-3-phenylpropanoyl-CoA + NAD+→3-oxo-3-phenylpropanoyl-CoA + NADH + H+ (EC 1.1.1.35)
Ga0059261_0837 -0.1
Ga0059261_2534 -0.2
Ga0059261_2816 -0.1
Ga0059261_2827 -0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-3-phenylpropanoyl-CoA + coenzyme A→benzoyl-CoA + acetyl-CoA (EC 2.3.1.16)
Ga0059261_0982 -0.2
Ga0059261_1483 -1.3
Ga0059261_2108 -0.2
Ga0059261_2160 +0.1
Ga0059261_2808 -0.1
Ga0059261_2835 -0.0
Ga0059261_2867 +0.0
Ga0059261_2877 +0.0
Ga0059261_2888 +0.1
Ga0059261_3284 -0.2
benzoyl-CoA + H2O→benzoate + coenzyme A + H+
No genes
benzoyl-CoA + benzyl alcohol→benzyl benzoate + coenzyme A (EC 2.3.1.196)
No genes
benzyl benzoate + H2O→benzoate + benzyl alcohol + H+
No genes
Benzoate--CoA ligase:
benzoate + ATP + coenzyme A→benzoyl-CoA + AMP + diphosphate (EC 6.2.1.25)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information