MetaCyc Pathway: superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) in Sphingomonas koreensis DSMZ 15582

Reactions and Genes	Gentamicin 0.005 mg/ml
Acetyl-CoA C-acyltransferase: 2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
Ga0059261_0982	-0.2
Ga0059261_1483	-1.3
Ga0059261_2108	-0.2
Ga0059261_2160	+0.1
Ga0059261_2808	-0.1
Ga0059261_2835	-0.0
Ga0059261_2867	+0.0
Ga0059261_2877	+0.0
Ga0059261_2888	+0.1
Ga0059261_3284	-0.2
Hydroxymethylglutaryl-CoA synthase: acetoacetyl-CoA + acetyl-CoA + H2O→(S)-3-hydroxy-3-methylglutaryl-CoA + coenzyme A + H+ (EC 2.3.3.10)
No genes
Hydroxymethylglutaryl-CoA reductase (NADPH) (in reverse): (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+→(R)-mevalonate + coenzyme A + 2 NADP+ (EC 1.1.1.34)
No genes
Mevalonate kinase: (R)-mevalonate + ATP→(R)-5-phosphomevalonate + ADP + H+ (EC 2.7.1.36)
No genes
Phosphomevalonate kinase: (R)-5-phosphomevalonate + ATP→(R)-mevalonate diphosphate + ADP (EC 2.7.4.2)
No genes
Diphosphomevalonate decarboxylase: (R)-mevalonate diphosphate + ATP→3-methylbut-3-en-1-yl diphosphate + ADP + CO2 + phosphate (EC 4.1.1.33)
No genes
Isopentenyl-diphosphate Delta-isomerase: 3-methylbut-3-en-1-yl diphosphate→prenyl diphosphate (EC 5.3.3.2)
No genes
Dimethylallyltranstransferase: prenyl diphosphate + 3-methylbut-3-en-1-yl diphosphate→geranyl diphosphate + diphosphate (EC 2.5.1.1)
Ga0059261_1008	+0.2
Geranyltranstransferase: geranyl diphosphate + 3-methylbut-3-en-1-yl diphosphate→(2E,6E)-farnesyl diphosphate + diphosphate (EC 2.5.1.10)
Ga0059261_1008	+0.2
Farnesyltranstransferase: (2E,6E)-farnesyl diphosphate + 3-methylbut-3-en-1-yl diphosphate→geranylgeranyl diphosphate + diphosphate (EC 2.5.1.29)
Ga0059261_1008	+0.2

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information