MetaCyc Pathway: superpathway of L-serine and glycine biosynthesis I in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes Choline Lysine 20 mM
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Phosphoglycerate dehydrogenase:
3-phospho-D-glycerate + NAD+→3-phosphooxypyruvate + NADH + H+ (EC 1.1.1.95)
Pf6N2E2_1079 +0.2
Pf6N2E2_2725 -1.1
Pf6N2E2_3246 N.D.
Pf6N2E2_372 -0.1
Pf6N2E2_3932 +0.0
Pf6N2E2_562 -0.0
Pf6N2E2_6020 -0.0
Phosphoserine transaminase (in reverse):
3-phosphooxypyruvate + L-glutamate→O-phospho-L-serine + 2-oxoglutarate (EC 2.6.1.52)
Pf6N2E2_2521 N.D.
Phosphoserine phosphatase:
O-phospho-L-serine + H2O→L-serine + phosphate (EC 3.1.3.3)
Pf6N2E2_1589 -0.2
Pf6N2E2_3630 -0.0
Pf6N2E2_3940 -0.0
Pf6N2E2_4563 -0.1
Pf6N2E2_5785 +0.0
Pf6N2E2_6055 +0.2
Glycine hydroxymethyltransferase:
L-serine + a tetrahydrofolate→glycine + a 5,10-methylenetetrahydrofolate + H2O (EC 2.1.2.1)
Pf6N2E2_4717 -0.3
Pf6N2E2_5082 N.D.
Pf6N2E2_5083 +0.2
Pf6N2E2_5295 -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information