MetaCyc Pathway: adipate degradation in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes Dimethyl Sulfoxide 7.5 vol%
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Succinate--CoA ligase (ADP-forming):
adipate + ATP + coenzyme A→adipoyl-CoA + ADP + phosphate (EC 6.2.1.5)
Pf6N2E2_5858 N.D.
Pf6N2E2_5859 N.D.
adipoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-5-carboxy-2-pentenoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
Pf6N2E2_1727 +0.0
Pf6N2E2_3686 +0.1
Pf6N2E2_4766 -2.0
Pf6N2E2_4768 -0.0
Pf6N2E2_4769 +0.0
Pf6N2E2_5026 -0.0
Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H2O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)
Pf6N2E2_1013 -0.1
Pf6N2E2_1046 -0.0
Pf6N2E2_1147 -0.1
Pf6N2E2_1149 -0.1
Pf6N2E2_1269 -0.2
Pf6N2E2_1833 +0.1
Pf6N2E2_1834 +0.1
Pf6N2E2_1835 +0.3
Pf6N2E2_1840 -0.4
Pf6N2E2_1850 +0.1
Pf6N2E2_1922 -0.1
Pf6N2E2_1934 -0.1
Pf6N2E2_1935 -0.0
Pf6N2E2_2290 N.D.
Pf6N2E2_2773 -0.0
Pf6N2E2_3894 +0.1
Pf6N2E2_5493 -0.0
Pf6N2E2_6000 -0.0
Pf6N2E2_6004 N.D.
Pf6N2E2_742 +0.0
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipoyl-CoA + NADH + H+ (EC 1.1.1.35)
Pf6N2E2_1833 +0.1
Pf6N2E2_1850 +0.1
Pf6N2E2_1922 -0.1
Pf6N2E2_2290 N.D.
Pf6N2E2_3894 +0.1
Pf6N2E2_4690 -0.0
Pf6N2E2_6000 -0.0
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)
Pf6N2E2_2835 -0.7

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information