MetaCyc Pathway: glycine betaine degradation I in Burkholderia phytofirmans PsJN

Reactions and Genes	Carnitine Hydrochloride (N)
Betaine--homocysteine S-methyltransferase: glycine betaine + L-homocysteine→N,N-dimethylglycine + L-methionine (EC 2.1.1.5)
No genes
Dimethylglycine oxidase: N,N-dimethylglycine + dioxygen + a tetrahydrofolate→sarcosine + hydrogen peroxide + a 5,10-methylenetetrahydrofolate (EC 1.5.3.10)
No genes
sarcosine + dioxygen + a tetrahydrofolate→glycine + hydrogen peroxide + a 5,10-methylenetetrahydrofolate (EC 1.5.3.24)
BPHYT_RS25105	-2.4
Sarcosine oxidase: sarcosine + dioxygen + H2O→glycine + formaldehyde + hydrogen peroxide (EC 1.5.3.1)
BPHYT_RS09370	+0.3
BPHYT_RS09375	-0.1
BPHYT_RS21990	+0.1
BPHYT_RS24345	N.D.
BPHYT_RS25105	-2.4
BPHYT_RS25110	-5.3
BPHYT_RS25115	-3.1
BPHYT_RS25120	N.D.
BPHYT_RS30165	+0.2
BPHYT_RS32315	N.D.
BPHYT_RS32645	+0.1
BPHYT_RS35025	-0.2
Glycine hydroxymethyltransferase (in reverse): glycine + a 5,10-methylenetetrahydrofolate + H2O→L-serine + a tetrahydrofolate (EC 2.1.2.1)
BPHYT_RS01260	+0.1
BPHYT_RS03725	-1.6
BPHYT_RS25180	-3.5
L-serine ammonia-lyase: L-serine→2-aminoprop-2-enoate + H2O (EC 4.3.1.17)
BPHYT_RS19340	+0.1
BPHYT_RS25100	-1.6
Tryptophanase: 2-aminoprop-2-enoate→2-iminopropanoate (spontaneous) (EC 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
BPHYT_RS03115	-0.1
BPHYT_RS19340	+0.1
BPHYT_RS25100	-1.6
2-iminopropanoate + H2O→pyruvate + ammonium (spontaneous) (EC 3.5.99.10; 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
BPHYT_RS03115	-0.1
BPHYT_RS19340	+0.1
BPHYT_RS25100	-1.6
BPHYT_RS29300	-0.0

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information