MetaCyc Pathway: serotonin degradation in Azospirillum brasilense Sp245

Add experiment(s):


Reactions and Genes L-Lysine (N)
remove
Aryl sulfotransferase:
serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase:
serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)):
5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
AZOBR_RS22315 +0.1
AZOBR_RS26825 +0.1
AZOBR_RS29185 +0.1
AZOBR_RS29750 -0.1
AZOBR_RS31000 -0.0
AZOBR_RS32620 -2.6
Alcohol dehydrogenase (in reverse):
5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
AZOBR_RS06065 +0.0
AZOBR_RS10415 +0.2
AZOBR_RS13230 +0.0
AZOBR_RS16515 +0.1
AZOBR_RS20975 -0.2
AZOBR_RS26265 -0.1
AZOBR_RS26520 +0.4
AZOBR_RS27605 -0.1
AZOBR_RS28580 +0.3
AZOBR_RS32240 -0.3
Aryl sulfotransferase:
5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information