MetaCyc Pathway: superpathway of L-methionine biosynthesis (transsulfuration) in Burkholderia phytofirmans PsJN

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Reactions and Genes L-Glutamine (N)
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
BPHYT_RS00155 -0.1
BPHYT_RS04100 N.D.
BPHYT_RS05430 +0.0
BPHYT_RS05975 +0.1
BPHYT_RS06770 +0.1
BPHYT_RS08040 +0.1
BPHYT_RS08950 -1.8
BPHYT_RS09580 +0.2
BPHYT_RS10265 -0.0
BPHYT_RS10440 -0.0
BPHYT_RS13065 +0.1
BPHYT_RS13450 +0.4
BPHYT_RS15405 +0.1
BPHYT_RS15820 +0.2
BPHYT_RS21060 -0.4
BPHYT_RS21560 +0.2
BPHYT_RS21610 -0.1
BPHYT_RS21730 +0.1
BPHYT_RS22065 -0.0
BPHYT_RS22425 -0.1
BPHYT_RS26535 -0.1
BPHYT_RS27000 +0.1
BPHYT_RS28370 -0.1
BPHYT_RS28685 +0.3
BPHYT_RS28695 -0.1
BPHYT_RS30590 +0.3
BPHYT_RS30680 +0.0
BPHYT_RS35285 +0.1
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
BPHYT_RS12410 N.D.
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
BPHYT_RS33895 N.D.
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
BPHYT_RS08955 -5.7
Homoserine O-succinyltransferase:
L-homoserine + succinyl-CoA→O-succinyl-L-homoserine + coenzyme A (EC 2.3.1.46)
No genes
Cystathionine gamma-synthase:
O-succinyl-L-homoserine + L-cysteine→L-cystathionine + H+ + succinate (EC 2.5.1.48)
BPHYT_RS13720 +0.1
BPHYT_RS33835 -7.7
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate (EC 4.4.1.13)
No genes
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate (EC 2.1.1.14)
BPHYT_RS26655 -0.2
Methionine synthase:
L-homocysteine + a 5-methyltetrahydrofolate→L-methionine + a tetrahydrofolate (EC 2.1.1.13)
BPHYT_RS02305 -1.3
BPHYT_RS02310 -1.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information