MetaCyc Pathway: tetrapyrrole biosynthesis II (from glycine) in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes Rifampicin 0.003 mg/ml
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5-aminolevulinate synthase:
glycine + H+ + succinyl-CoA→5-aminolevulinate + CO2 + coenzyme A (EC 2.3.1.37)
No genes
Porphobilinogen synthase:
2 5-aminolevulinate→porphobilinogen + H+ + 2 H2O (EC 4.2.1.24)
Pf6N2E2_2146 -0.3
Pf6N2E2_4452 -0.5
Hydroxymethylbilane synthase:
4 porphobilinogen + H2O→preuroporphyrinogen + 4 ammonium (EC 2.5.1.61)
Pf6N2E2_4431 N.D.
Uroporphyrinogen-III synthase:
preuroporphyrinogen→uroporphyrinogen-III + H2O (EC 4.2.1.75)
Pf6N2E2_4432 +1.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information