MetaCyc Pathway: thiamine diphosphate salvage IV (yeast) in Pseudomonas fluorescens FW300-N2E3

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Reactions and Genes Sisomicin 0.008 mg/ml
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Thiaminase:
thiamine + H2O→4-amino-2-methyl-5-pyrimidinemethanol + 5-(2-hydroxyethyl)-4-methylthiazole + H+ (EC 3.5.99.2)
No genes
Hydroxymethylpyrimidine kinase:
4-amino-2-methyl-5-pyrimidinemethanol + ATP→4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H+ (EC 2.7.1.49)
AO353_06350 +2.2
Hydroxyethylthiazole kinase:
5-(2-hydroxyethyl)-4-methylthiazole + ATP→4-methyl-5-(2-phosphooxyethyl)thiazole + ADP + H+ (EC 2.7.1.50)
No genes
Phosphomethylpyrimidine kinase:
4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP→4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP (EC 2.7.4.7)
AO353_06350 +2.2
Thiamine-phosphate diphosphorylase:
4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)thiazole + H+→thiamine phosphate + diphosphate (EC 2.5.1.3)
AO353_06355 +1.1
thiamine phosphate + H2O→thiamine + phosphate (EC 3.1.3.100)
No genes
Thiamine diphosphokinase:
thiamine + ATP→thiamine diphosphate + AMP + H+ (EC 2.7.6.2)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information