MetaCyc Pathway: superpathway of L-methionine salvage and degradation in Burkholderia phytofirmans PsJN

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Reactions and Genes L-Glutamic (N)
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Betaine--homocysteine S-methyltransferase:
L-homocysteine + glycine betaine→L-methionine + N,N-dimethylglycine (EC 2.1.1.5)
No genes
Homocysteine S-methyltransferase:
L-homocysteine + S-methyl-L-methionine→2 L-methionine + H+ (EC 2.1.1.10)
No genes
Methionine synthase:
L-homocysteine + a 5-methyltetrahydrofolate→L-methionine + a tetrahydrofolate (EC 2.1.1.13)
BPHYT_RS02305 -1.8
BPHYT_RS02310 -1.6
Methionine adenosyltransferase:
L-methionine + ATP + H2O→S-adenosyl-L-methionine + diphosphate + phosphate (EC 2.5.1.6)
BPHYT_RS01675 N.D.
S-adenosyl-L-homocysteine + a methylated methyl acceptor + H+→S-adenosyl-L-methionine + a demethylated methyl acceptor
No genes
S-adenosyl-L-homocysteine + H2O→L-homocysteine + adenosine (EC 3.13.2.1)
BPHYT_RS17740 N.D.
BPHYT_RS18715 N.D.
BPHYT_RS19095 N.D.
Cystathionine beta-synthase:
L-homocysteine + L-serine→L-cystathionine + H2O (EC 4.2.1.22)
No genes
Cystathionine gamma-lyase:
L-cystathionine + H2O→L-cysteine + 2-oxobutanoate + ammonium (EC 4.4.1.1)
No genes
Cysteine dioxygenase:
L-cysteine + dioxygen→3-sulfino-L-alanine + H+ (EC 1.13.11.20)
BPHYT_RS07645 -0.1
2-oxoisovalerate dehydrogenase (acylating):
2-oxobutanoate + coenzyme A + NAD+→propanoyl-CoA + CO2 + NADH (EC 1.2.1.25)
No genes
3-sulfino-L-alanine + 2-oxoglutarate→3-sulfinopyruvate + L-glutamate
No genes
Propionyl-CoA carboxylase:
propanoyl-CoA + ATP + hydrogen carbonate→(S)-methylmalonyl-CoA + ADP + H+ + phosphate (EC 6.4.1.3)
BPHYT_RS12420 N.D.
BPHYT_RS33860 N.D.
3-sulfinopyruvate + H2O→pyruvate + sulfite + H+ (spontaneous)
No genes
Methylmalonyl-CoA epimerase (in reverse):
(S)-methylmalonyl-CoA→(R)-methylmalonyl-CoA (EC 5.1.99.1)
No genes
Methylmalonyl-CoA mutase:
(R)-methylmalonyl-CoA→succinyl-CoA (EC 5.4.99.2)
BPHYT_RS02085 -0.0
Sulfite oxidase:
sulfite + dioxygen + H2O→sulfate + hydrogen peroxide (EC 1.8.3.1)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information