MetaCyc Pathway: superpathway of sulfate assimilation and cysteine biosynthesis in Caulobacter crescentus NA1000

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Reactions and Genes PYE with copper (II) chloride 0.25 mM
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Phosphoglycerate dehydrogenase:
3-phospho-D-glycerate + NAD+→3-phosphooxypyruvate + NADH + H+ (EC 1.1.1.95)
CCNA_02230 -0.3
CCNA_03322 +1.6
Sulfate adenylyltransferase:
sulfate + ATP + H+→adenosine 5'-phosphosulfate + diphosphate (EC 2.7.7.4)
CCNA_01549 +1.0
CCNA_01550 +0.5
Adenylyl-sulfate kinase:
adenosine 5'-phosphosulfate + ATP→3'-phosphoadenylyl-sulfate + ADP + H+ (EC 2.7.1.25)
CCNA_01549 +1.0
Phosphoserine transaminase (in reverse):
3-phosphooxypyruvate + L-glutamate→O-phospho-L-serine + 2-oxoglutarate (EC 2.6.1.52)
CCNA_03323 +1.8
Phosphoadenylyl-sulfate reductase (thioredoxin) (in reverse):
3'-phosphoadenylyl-sulfate + a reduced thioredoxin→sulfite + adenosine 3',5'-bisphosphate + an oxidized thioredoxin + 2 H+ (EC 1.8.4.8)
CCNA_01179 +1.2
Phosphoserine phosphatase:
O-phospho-L-serine + H2O→L-serine + phosphate (EC 3.1.3.3)
CCNA_02182 +0.4
Serine O-acetyltransferase:
L-serine + acetyl-CoA→O-acetyl-L-serine + coenzyme A (EC 2.3.1.30)
CCNA_02734 N.D.
Sulfite reductase (NADPH) (in reverse):
sulfite + 3 NADPH + 5 H+→hydrogen sulfide + 3 NADP+ + 3 H2O (EC 1.8.1.2)
CCNA_01177 +0.5
CCNA_03159 -2.5
Cysteine synthase:
O-acetyl-L-serine + hydrogen sulfide→L-cysteine + acetate + H+ (EC 2.5.1.47)
CCNA_01493 +0.6
CCNA_03740 +2.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information