MetaCyc Pathway: TCA cycle VI (Helicobacter) in Pedobacter sp. GW460-11-11-14-LB5

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Reactions and Genes Gly-DL-Asp (N)
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2-oxoglutarate synthase:
2-oxoglutarate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→succinyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.3)
No genes
3-oxoacid CoA-transferase:
succinyl-CoA + acetoacetate→succinate + acetoacetyl-CoA (EC 2.8.3.5)
CA265_RS06305 +0.3
CA265_RS06310 +0.1
Succinate dehydrogenase (ubiquinone) (in reverse):
succinate[in] + a menaquinone→fumarate[in] + a menaquinol (EC 1.3.5.1)
No genes
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
CA265_RS23855 N.D.
(S)-malate + a menaquinone→oxaloacetate + a menaquinol (EC 1.1.5.4)
CA265_RS17145 +1.6
Citrate (Si)-synthase:
oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
CA265_RS08845 N.D.
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
CA265_RS16400 -0.3
CA265_RS16405 -2.3
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
CA265_RS16400 -0.3
CA265_RS16405 -2.3
Isocitrate dehydrogenase (NADP(+)):
D-threo-isocitrate + NADP+→2-oxoglutarate + CO2 + NADPH (EC 1.1.1.42)
CA265_RS02350 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information