MetaCyc Pathway: (2S)-ethylmalonyl-CoA biosynthesis in Rhodospirillum rubrum S1H

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Reactions and Genes Hexanoic 21 mM; anaerobic
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
Rru_A0274 -1.1
Rru_A1310 -1.8
Rru_A1380 +0.3
Rru_A1469 N.D.
Rru_A1946 -0.1
Rru_A3387 N.D.
Acetoacetyl-CoA reductase (in reverse):
acetoacetyl-CoA + NADPH + H+→(3R)-3-hydroxybutanoyl-CoA + NADP+ (EC 1.1.1.36)
Rru_A0273 +0.2
3-hydroxybutyryl-CoA dehydratase:
(3R)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.55)
Rru_A2964 -0.2
crotonyl-CoA + CO2 + NADPH→(2S)-ethylmalonyl-CoA + NADP+ (EC 1.3.1.85)
Rru_A3063 -1.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information