MetaCyc Pathway: glycine betaine degradation III in Sinorhizobium meliloti 1021

Reactions and Genes	L-Serine (N)
glycine betaine + NADH + dioxygen + H+→N,N-dimethylglycine + formaldehyde + NAD+ + H2O (EC 1.14.13.251)
No genes
N,N-dimethylglycine + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O→sarcosine + formaldehyde + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.5.7.3)
No genes
sarcosine + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O→glycine + formaldehyde + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.5.7.3)
No genes
Glycine hydroxymethyltransferase (in reverse): glycine + a 5,10-methylenetetrahydrofolate + H2O→L-serine + a tetrahydrofolate (EC 2.1.2.1)
SMa2135	+0.1
SMc01770	-3.6
L-serine ammonia-lyase: L-serine→2-aminoprop-2-enoate + H2O (EC 4.3.1.17)
SMc01256	-1.9
Tryptophanase: 2-aminoprop-2-enoate→2-iminopropanoate (spontaneous) (EC 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
SMc01256	-1.9
2-iminopropanoate + H2O→pyruvate + ammonium (spontaneous) (EC 3.5.99.10; 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
SMc01256	-1.9

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information