MetaCyc Pathway: TCA cycle VI (Helicobacter) in Shewanella amazonensis SB2B

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Reactions and Genes L-Leucine (N)
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2-oxoglutarate synthase:
2-oxoglutarate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→succinyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.3)
No genes
3-oxoacid CoA-transferase:
succinyl-CoA + acetoacetate→succinate + acetoacetyl-CoA (EC 2.8.3.5)
Sama_0518 +0.2
Sama_0519 -0.0
Sama_1356 -1.3
Sama_1357 -1.5
Succinate dehydrogenase (ubiquinone) (in reverse):
succinate[in] + a menaquinone→fumarate[in] + a menaquinol (EC 1.3.5.1)
Sama_3219 (frdB) -0.4
Sama_3222 -0.3
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
Sama_0822 +0.0
Sama_1688 N.D.
(S)-malate + a menaquinone→oxaloacetate + a menaquinol (EC 1.1.5.4)
No genes
Citrate (Si)-synthase:
oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
Sama_1422 (gltA) -2.4
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
Sama_0382 N.D.
Sama_3296 -2.9
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
Sama_0382 N.D.
Sama_3296 -2.9
Isocitrate dehydrogenase (NADP(+)):
D-threo-isocitrate + NADP+→2-oxoglutarate + CO2 + NADPH (EC 1.1.1.42)
Sama_2059 -3.7

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information