MetaCyc Pathway: coumarin biosynthesis (via 2-coumarate) in Bacteroides thetaiotaomicron VPI-5482

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Reactions and Genes b-Glucan from Beet (1,2-b-Glucan); filtered 2.5 mg/ml (C)
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Trans-cinnamate 2-monooxygenase:
trans-cinnamate + NADPH + dioxygen + H+→trans-2-coumarate + NADP+ + H2O (EC 1.14.13.14)
No genes
2-coumarate O-beta-glucosyltransferase:
trans-2-coumarate + UDP-α-D-glucose→trans-β-D-glucosyl-2-hydroxycinnamate + H+ + UDP (EC 2.4.1.114)
No genes
trans-β-D-glucosyl-2-hydroxycinnamate→cis-β-D-glucosyl-2-hydroxycinnamate
No genes
Beta-glucosidase:
cis-β-D-glucosyl-2-hydroxycinnamate + H2O→cis-2-coumarate + D-glucopyranose (EC 3.2.1.21)
BT1778 -0.0
BT1780 +0.2
BT1781 -0.0
BT1872 -0.2
BT2854 +0.1
BT3009 +0.0
BT3300 -0.2
BT3314 -0.1
BT3566 +0.1
BT3567 -3.5
BT4714 -0.1
cis-2-coumarate + H+→coumarin + H2O (spontaneous)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information