MetaCyc Pathway: L-proline biosynthesis I (from L-glutamate) in Bacteroides thetaiotaomicron VPI-5482

Reactions and Genes	Mannan from Saccharomyces cerevisiae; filtered 2.5 mg/ml (C)
Glutamate 5-kinase: L-glutamate + ATP→γ-L-glutamyl 5-phosphate + ADP (EC 2.7.2.11)
BT3719	-2.0
Glutamate-5-semialdehyde dehydrogenase (in reverse): γ-L-glutamyl 5-phosphate + NADPH + H+→L-glutamate 5-semialdehyde + NADP+ + phosphate (EC 1.2.1.41)
BT3718	-2.8
L-glutamate 5-semialdehyde→(S)-1-pyrroline-5-carboxylate + H+ + H2O (spontaneous)
No genes
Pyrroline-5-carboxylate reductase (in reverse): (S)-1-pyrroline-5-carboxylate + NAD(P)H + 2 H+→L-proline + NAD(P)+ (EC 1.5.1.2)
BT1902	+1.1
BT3757	-4.0

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information