MetaCyc Pathway: superpathway of heme b biosynthesis from glycine in Rhodopseudomonas palustris CGA009

Reactions and Genes	PM with succinate aerobic in dark
5-aminolevulinate synthase: glycine + H+ + succinyl-CoA→5-aminolevulinate + CO2 + coenzyme A (EC 2.3.1.37)
TX73_004400	N.D.
TX73_007985	+0.0
Porphobilinogen synthase: 2 5-aminolevulinate→porphobilinogen + H+ + 2 H2O (EC 4.2.1.24)
TX73_014055	N.D.
Hydroxymethylbilane synthase: 4 porphobilinogen + H2O→preuroporphyrinogen + 4 ammonium (EC 2.5.1.61)
TX73_007735	N.D.
Uroporphyrinogen-III synthase: preuroporphyrinogen→uroporphyrinogen-III + H2O (EC 4.2.1.75)
TX73_001330	N.D.
TX73_020895	+0.2
Uroporphyrinogen decarboxylase: uroporphyrinogen-III + 4 H+→coproporphyrinogen III + 4 CO2 (EC 4.1.1.37)
TX73_007755	N.D.
Coproporphyrinogen oxidase: coproporphyrinogen III + dioxygen + 2 H+→protoporphyrinogen IX + 2 CO2 + 2 H2O (EC 1.3.3.3)
TX73_007780	-1.6
Protoporphyrinogen oxidase: protoporphyrinogen IX + 3 dioxygen→protoporphyrin IX + 3 hydrogen peroxide (EC 1.3.3.4)
No genes
protoporphyrin IX + Fe2+→protoheme + 2 H+ (EC 4.98.1.1)
TX73_004510	N.D.

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information