MetaCyc Pathway: streptorubin B biosynthesis in Rhodopseudomonas palustris CGA009

Reactions and Genes	PM with succinate and Sodium Formate aerobic in dark
	remove
Beta-ketoacyl-acyl-carrier-protein synthase III: acetyl-CoA + a malonyl-[acp] + H⁺→an acetoacetyl-[acp] + CO₂ + coenzyme A (EC 2.3.1.180)
TX73_006660	-0.2
TX73_014200	N.D.
L-proline + ATP + a holo-[RedO prolyl-carrier protein]→an L-prolyl-[RedO prolyl-carrier protein] + AMP + diphosphate + H⁺ (EC 6.2.1.53)
No genes
malonyl-CoA + a holo-[RedN acyl-carrier protein/polyketide synthase]→a malonyl-[RedN] + coenzyme A
No genes
malonyl-CoA + a RedL polyketide synthase→a malonyl-[RedL polyketide synthase] + coenzyme A
No genes
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse): an acetoacetyl-[acp] + NADPH + H⁺→a (3R)-3-hydroxybutanoyl-[acp] + NADP⁺ (EC 1.1.1.100)
TX73_000560	+0.1
TX73_002485	+0.1
TX73_003390	+0.1
TX73_004045	+0.3
TX73_004610	-0.3
TX73_004615	+0.0
TX73_008650	-0.2
TX73_008655	+0.0
TX73_008935	+0.1
TX73_011140	-0.0
TX73_012495	+0.3
TX73_015900	N.D.
TX73_016995	-0.0
TX73_017080	+0.0
TX73_017465	+0.1
TX73_017980	+0.4
TX73_018405	-1.3
TX73_018410	+0.0
TX73_020990	-0.7
TX73_023875	-0.1
TX73_024180	+0.1
an L-prolyl-[RedO prolyl-carrier protein] + 2 an oxidized electron-transfer flavoprotein + 2 H⁺→a 1H-pyrrole-2-carbonyl-[RedO prolyl-carrier protein] + 2 a reduced electron-transfer flavoprotein (EC 1.3.8.14)
No genes
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase: a (3R)-3-hydroxybutanoyl-[acp]→a (2E)-but-2-enoyl-[acp] + H₂O (EC 4.2.1.59)
TX73_002210	N.D.
TX73_010415	-0.0
TX73_015090	N.D.
a 1H-pyrrole-2-carbonyl-[RedO prolyl-carrier protein] + a [RedX protein]-L-cysteine→a [RedX acyl-carrier protein]-(1H-pyrrole-2-carbonyl)-L-cysteine + a holo-[RedO prolyl-carrier protein]
No genes
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse): a (2E)-but-2-enoyl-[acp] + NADH + H⁺→a butanoyl-[acp] + NAD⁺ (EC 1.3.1.9)
TX73_002220	N.D.
TX73_006160	-0.0
TX73_010005	+0.1
TX73_011140	-0.0
TX73_016095	-0.0
TX73_023730	+0.2
a [RedX acyl-carrier protein]-(1H-pyrrole-2-carbonyl)-L-cysteine + a malonyl-[RedN] + H⁺→a 3-oxo-3-(1H-pyrrol-2-yl)propanoyl-[RedN] + CO₂ + a [RedX protein]-L-cysteine
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II: a butanoyl-[acp] + a malonyl-[acp] + H⁺→a 3-oxohexanoyl-[acp] + a soluble [acyl-carrier protein] + CO₂ (EC 2.3.1.179; 2.3.1.41)
TX73_002215	N.D.
TX73_010405	N.D.
TX73_010410	N.D.
TX73_015890	N.D.
a 3-oxo-3-(1H-pyrrol-2-yl)propanoyl-[RedN] + L-serine→4-hydroxy-2,2'-bipyrrole-5-methanol + CO₂ + a holo-[RedN acyl-carrier protein/polyketide synthase] + H₂O
No genes
4-hydroxy-2,2'-bipyrrole-5-methanol + NAD(P)⁺→4-hydroxy-2,2'-bipyrrole-5-carbaldehyde + NAD(P)H + H⁺
No genes
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse): a 3-oxohexanoyl-[acp] + NADPH + H⁺→a (3R)-3-hydroxyhexanoyl-[acp] + NADP⁺ (EC 1.1.1.100)
TX73_000560	+0.1
TX73_002485	+0.1
TX73_003390	+0.1
TX73_004045	+0.3
TX73_004610	-0.3
TX73_004615	+0.0
TX73_008650	-0.2
TX73_008655	+0.0
TX73_008935	+0.1
TX73_011140	-0.0
TX73_012495	+0.3
TX73_015900	N.D.
TX73_016995	-0.0
TX73_017080	+0.0
TX73_017465	+0.1
TX73_017980	+0.4
TX73_018405	-1.3
TX73_018410	+0.0
TX73_020990	-0.7
TX73_023875	-0.1
TX73_024180	+0.1
4-hydroxy-2,2'-bipyrrole-5-carbaldehyde + S-adenosyl-L-methionine→4-methoxy-2,2'-bipyrrole-5-carbaldehyde + S-adenosyl-L-homocysteine + H⁺
No genes
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase: a (3R)-3-hydroxyhexanoyl-[acp]→a (2E)-hex-2-enoyl-[acp] + H₂O (EC 4.2.1.59)
TX73_002210	N.D.
TX73_010415	-0.0
TX73_015090	N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse): a (2E)-hex-2-enoyl-[acp] + NADH + H⁺→a hexanoyl-[acp] + NAD⁺ (EC 1.3.1.9)
TX73_002220	N.D.
TX73_006160	-0.0
TX73_010005	+0.1
TX73_011140	-0.0
TX73_016095	-0.0
TX73_023730	+0.2
Beta-ketoacyl-acyl-carrier-protein synthase II: a hexanoyl-[acp] + a malonyl-[acp] + H⁺→a 3-oxooctanoyl-[acp] + a soluble [acyl-carrier protein] + CO₂ (EC 2.3.1.179; 2.3.1.41)
TX73_002215	N.D.
TX73_010405	N.D.
TX73_010410	N.D.
TX73_015890	N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse): a 3-oxooctanoyl-[acp] + NADPH + H⁺→a (3R)-3-hydroxyoctanoyl-[acp] + NADP⁺ (EC 1.1.1.100)
TX73_000560	+0.1
TX73_002485	+0.1
TX73_003390	+0.1
TX73_004045	+0.3
TX73_004610	-0.3
TX73_004615	+0.0
TX73_008650	-0.2
TX73_008655	+0.0
TX73_008935	+0.1
TX73_011140	-0.0
TX73_012495	+0.3
TX73_015900	N.D.
TX73_016995	-0.0
TX73_017080	+0.0
TX73_017465	+0.1
TX73_017980	+0.4
TX73_018405	-1.3
TX73_018410	+0.0
TX73_020990	-0.7
TX73_023875	-0.1
TX73_024180	+0.1
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase: a (3R)-3-hydroxyoctanoyl-[acp]→a (2E)-oct-2-enoyl-[acp] + H₂O (EC 4.2.1.59)
TX73_002210	N.D.
TX73_010415	-0.0
TX73_015090	N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse): a (2E)-oct-2-enoyl-[acp] + NADH + H⁺→an octanoyl-[acp] + NAD⁺ (EC 1.3.1.9)
TX73_002220	N.D.
TX73_006160	-0.0
TX73_010005	+0.1
TX73_011140	-0.0
TX73_016095	-0.0
TX73_023730	+0.2
Beta-ketoacyl-acyl-carrier-protein synthase II: an octanoyl-[acp] + a malonyl-[acp] + H⁺→a 3-oxodecanoyl-[acp] + a soluble [acyl-carrier protein] + CO₂ (EC 2.3.1.179; 2.3.1.41)
TX73_002215	N.D.
TX73_010405	N.D.
TX73_010410	N.D.
TX73_015890	N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse): a 3-oxodecanoyl-[acp] + NADPH + H⁺→a (3R)-3-hydroxydecanoyl-[acp] + NADP⁺ (EC 1.1.1.100)
TX73_000560	+0.1
TX73_002485	+0.1
TX73_003390	+0.1
TX73_004045	+0.3
TX73_004610	-0.3
TX73_004615	+0.0
TX73_008650	-0.2
TX73_008655	+0.0
TX73_008935	+0.1
TX73_011140	-0.0
TX73_012495	+0.3
TX73_015900	N.D.
TX73_016995	-0.0
TX73_017080	+0.0
TX73_017465	+0.1
TX73_017980	+0.4
TX73_018405	-1.3
TX73_018410	+0.0
TX73_020990	-0.7
TX73_023875	-0.1
TX73_024180	+0.1
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase: a (3R)-3-hydroxydecanoyl-[acp]→a (2E)-dec-2-enoyl-[acp] + H₂O (EC 4.2.1.59)
TX73_002210	N.D.
TX73_010415	-0.0
TX73_015090	N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse): a (2E)-dec-2-enoyl-[acp] + NADH + H⁺→a decanoyl-[acp] + NAD⁺ (EC 1.3.1.9)
TX73_002220	N.D.
TX73_006160	-0.0
TX73_010005	+0.1
TX73_011140	-0.0
TX73_016095	-0.0
TX73_023730	+0.2
Beta-ketoacyl-acyl-carrier-protein synthase II: a decanoyl-[acp] + a malonyl-[acp] + H⁺→a 3-oxododecanoyl-[acp] + a soluble [acyl-carrier protein] + CO₂ (EC 2.3.1.179; 2.3.1.41)
TX73_002215	N.D.
TX73_010405	N.D.
TX73_010410	N.D.
TX73_015890	N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse): a 3-oxododecanoyl-[acp] + NADPH + H⁺→a (3R)-3-hydroxydodecanoyl-[acp] + NADP⁺ (EC 1.1.1.100)
TX73_000560	+0.1
TX73_002485	+0.1
TX73_003390	+0.1
TX73_004045	+0.3
TX73_004610	-0.3
TX73_004615	+0.0
TX73_008650	-0.2
TX73_008655	+0.0
TX73_008935	+0.1
TX73_011140	-0.0
TX73_012495	+0.3
TX73_015900	N.D.
TX73_016995	-0.0
TX73_017080	+0.0
TX73_017465	+0.1
TX73_017980	+0.4
TX73_018405	-1.3
TX73_018410	+0.0
TX73_020990	-0.7
TX73_023875	-0.1
TX73_024180	+0.1
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase: a (3R)-3-hydroxydodecanoyl-[acp]→a (2E)-dodec-2-enoyl-[acp] + H₂O (EC 4.2.1.59)
TX73_002210	N.D.
TX73_010415	-0.0
TX73_015090	N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse): a (2E)-dodec-2-enoyl-[acp] + NADH + H⁺→a dodecanoyl-[acp] + NAD⁺ (EC 1.3.1.9)
TX73_002220	N.D.
TX73_006160	-0.0
TX73_010005	+0.1
TX73_011140	-0.0
TX73_016095	-0.0
TX73_023730	+0.2
a malonyl-[RedL polyketide synthase] + a dodecanoyl-[RedQ acyl-carrier protein] + H⁺→a 3-oxotetradecanoyl-[RedL polyketide synthase] + CO₂ + a holo-[RedQ acyl-carrier protein]
No genes
a 3-oxotetradecanoyl-[RedL polyketide synthase] + glycine→5-undecyl-1,2-dihydropyrrol-3-one + CO₂ + a RedL polyketide synthase + H₂O
No genes
5-undecyl-1,2-dihydropyrrol-3-one + NAD(P)H + H⁺→2-undecylpyrrole + NAD(P)⁺ + H₂O
No genes
4-methoxy-2,2'-bipyrrole-5-carbaldehyde + 2-undecylpyrrole + ATP→undecylprodigiosin + ADP + H⁺ + phosphate
No genes
undecylprodigiosin + a reduced two electron carrier + dioxygen→streptorubin B + an oxidized electron carrier + 2 H₂O
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information