MetaCyc Pathway: superpathway of fatty acid biosynthesis I (E. coli) in Rhodopseudomonas palustris CGA009

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Reactions and Genes 4-Hydroxybenzoate (C)
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[Acyl-carrier-protein] S-acetyltransferase:
acetyl-CoA + a soluble [acyl-carrier protein]→an acetyl-[acp] + coenzyme A
(EC 2.3.1.38)
TX73_010405 N.D.
acetyl-CoA + a [carboxyl-carrier protein dimer]-N6-carboxybiotinyl-L-lysine→malonyl-CoA + a [biotin carboxyl-carrier-protein dimer]-N6-biotinyl-L-lysine (EC 2.1.3.15)
TX73_002635 N.D.
[Acyl-carrier-protein] S-malonyltransferase:
malonyl-CoA + a soluble [acyl-carrier protein]→a malonyl-[acp] + coenzyme A
(EC 2.3.1.39)
TX73_015905 N.D.
Beta-ketoacyl-acyl-carrier-protein synthase III:
acetyl-CoA + a malonyl-[acp] + H+→an acetoacetyl-[acp] + CO2 + coenzyme A
(EC 2.3.1.180)
TX73_006660 -0.1
TX73_014200 N.D.
Beta-ketoacyl-acyl-carrier-protein synthase II:
an acetyl-[acp] + a malonyl-[acp] + H+→an acetoacetyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
TX73_002215 N.D.
TX73_010405 N.D.
TX73_010410 N.D.
TX73_015890 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxoacyl-[acyl-carrier protein] + NADPH + H+→a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+
(EC 1.1.1.100)
TX73_000560 -0.2
TX73_002485 +0.2
TX73_003390 -4.1
TX73_004045 -0.0
TX73_004610 -0.1
TX73_004615 -0.2
TX73_008650 -0.1
TX73_008655 -0.0
TX73_008935 +0.1
TX73_011140 +0.1
TX73_012495 +0.1
TX73_015900 N.D.
TX73_016995 +0.0
TX73_017080 +0.0
TX73_017465 -0.1
TX73_017980 -0.1
TX73_018405 +0.1
TX73_018410 -0.1
TX73_020990 -0.5
TX73_023875 +0.3
TX73_024180 -0.0
TX73_024875 -0.0
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyacyl-[acyl-carrier protein]→a trans-2-enoyl-[acyl-carrier protein] + H2O
(EC 4.2.1.59)
TX73_002210 N.D.
TX73_010415 +0.1
TX73_015090 N.D.
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydecanoyl-[acp]→a (2E)-dec-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
TX73_002210 N.D.
TX73_010415 +0.1
TX73_015090 N.D.
Trans-2-decenoyl-[acyl-carrier-protein] isomerase:
a (2E)-dec-2-enoyl-[acp]→a (3Z)-dec-3-enoyl-[acp]
(EC 5.3.3.14)
TX73_002210 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a trans-2-enoyl-[acyl-carrier protein] + NADH + H+→a 2,3,4-saturated fatty acyl-[acp] + NAD+
(EC 1.3.1.9)
TX73_002220 N.D.
TX73_006160 -0.0
TX73_010005 +0.1
TX73_011140 +0.1
TX73_016095 +0.1
TX73_023730 -0.2
Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) (in reverse):
a trans-2-enoyl-[acyl-carrier protein] + NADPH + H+→a 2,3,4-saturated fatty acyl-[acp] + NADP+
(EC 1.3.1.10; 1.3.1.104; 1.3.1.39)
TX73_009530 -0.0
Beta-ketoacyl-acyl-carrier-protein synthase II:
a 2,3,4-saturated fatty acyl-[acp] + a malonyl-[acp] + H+→a 3-oxoacyl-[acyl-carrier protein] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
TX73_002215 N.D.
TX73_010405 N.D.
TX73_010410 N.D.
TX73_015890 N.D.
Beta-ketoacyl-acyl-carrier-protein synthase II:
a (3Z)-dec-3-enoyl-[acp] + a malonyl-[acp] + H+→a (5Z)-3-oxododec-5-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
TX73_002215 N.D.
TX73_010405 N.D.
TX73_010410 N.D.
TX73_015890 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a (5Z)-3-oxododec-5-enoyl-[acp] + NADPH + H+→a (3R,5Z)-3-hydroxydodec-5-enoyl-[acp] + NADP+
(EC 1.1.1.100)
TX73_000560 -0.2
TX73_002485 +0.2
TX73_003390 -4.1
TX73_004045 -0.0
TX73_004610 -0.1
TX73_004615 -0.2
TX73_008650 -0.1
TX73_008655 -0.0
TX73_008935 +0.1
TX73_011140 +0.1
TX73_012495 +0.1
TX73_015900 N.D.
TX73_016995 +0.0
TX73_017080 +0.0
TX73_017465 -0.1
TX73_017980 -0.1
TX73_018405 +0.1
TX73_018410 -0.1
TX73_020990 -0.5
TX73_023875 +0.3
TX73_024180 -0.0
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R,5Z)-3-hydroxydodec-5-enoyl-[acp]→a (2E,5Z)-dodeca-3,5-dienoyl-[acp] + H2O
(EC 4.2.1.59)
TX73_002210 N.D.
TX73_010415 +0.1
TX73_015090 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E,5Z)-dodeca-3,5-dienoyl-[acp] + NADH + H+→a (5Z)-dodec-5-enoyl-[acp] + NAD+
(EC 1.3.1.9)
TX73_002220 N.D.
TX73_006160 -0.0
TX73_010005 +0.1
TX73_011140 +0.1
TX73_016095 +0.1
TX73_023730 -0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information