MetaCyc Pathway: pyruvate fermentation to hexanol (engineered) in Rhodopseudomonas palustris CGA009

Add experiment(s):


Reactions and Genes 4-Hydroxybenzoate (C)
remove
Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
No genes
Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
TX73_002660 -0.3
TX73_002750 -0.6
TX73_004215 +0.0
TX73_008765 +0.2
TX73_009030 +0.1
TX73_011915 +0.2
TX73_016520 +0.0
TX73_017920 +0.0
TX73_017940 -0.0
TX73_019245 +0.0
TX73_022530 +0.0
3-hydroxyacyl-CoA dehydrogenase (in reverse):
acetoacetyl-CoA + NADH + H+→(S)-3-hydroxybutanoyl-CoA + NAD+ (EC 1.1.1.35)
TX73_004220 +0.2
TX73_008775 -0.0
TX73_011910 +0.2
TX73_018155 -0.1
TX73_019255 -0.1
TX73_024670 +1.0
(S)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.150)
TX73_001990 -0.1
TX73_002165 +0.0
TX73_002395 +0.0
TX73_002500 +0.1
TX73_002510 -0.0
TX73_003370 +0.4
TX73_004930 -0.2
TX73_006355 +0.1
TX73_007240 -0.0
TX73_008810 +0.0
TX73_009040 -0.1
TX73_009055 +0.0
TX73_009185 +0.1
TX73_009315 +1.5
TX73_011975 -0.2
TX73_014325 -0.0
TX73_017085 -0.1
TX73_019255 -0.1
TX73_019650 +0.0
TX73_022390 +0.0
TX73_022490 -0.3
Trans-2-enoyl-CoA reductase (NAD(+)) (in reverse):
crotonyl-CoA + NADH + H+→butanoyl-CoA + NAD+ (EC 1.3.1.44)
TX73_002490 -0.0
TX73_003380 +0.2
TX73_003825 +0.1
TX73_005120 -0.1
TX73_006350 -0.1
TX73_008280 -0.0
TX73_008790 -0.1
TX73_008795 +0.0
TX73_008800 +0.0
TX73_009060 -0.2
TX73_011025 +0.2
TX73_011920 +0.1
TX73_019235 -3.0
TX73_023655 -0.1
Acetyl-CoA C-acyltransferase:
acetyl-CoA + butanoyl-CoA→3-oxohexanoyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
TX73_002660 -0.3
TX73_002750 -0.6
TX73_004215 +0.0
TX73_008765 +0.2
TX73_009030 +0.1
TX73_011915 +0.2
TX73_016520 +0.0
TX73_017920 +0.0
TX73_017940 -0.0
TX73_019245 +0.0
TX73_022530 +0.0
3-hydroxyacyl-CoA dehydrogenase (in reverse):
3-oxohexanoyl-CoA + NADH + H+→(S)-3-hydroxyhexanoyl-CoA + NAD+ (EC 1.1.1.35)
TX73_004220 +0.2
TX73_008775 -0.0
TX73_011910 +0.2
TX73_018155 -0.1
TX73_019255 -0.1
Long-chain-enoyl-CoA hydratase:
(S)-3-hydroxyhexanoyl-CoA→(2E)-hex-2-enoyl-CoA + H2O (EC 4.2.1.74)
TX73_001990 -0.1
TX73_002165 +0.0
TX73_002395 +0.0
TX73_002500 +0.1
TX73_002510 -0.0
TX73_003370 +0.4
TX73_004930 -0.2
TX73_006355 +0.1
TX73_007240 -0.0
TX73_008810 +0.0
TX73_009040 -0.1
TX73_009055 +0.0
TX73_009185 +0.1
TX73_009315 +1.5
TX73_011975 -0.2
TX73_014325 -0.0
TX73_017085 -0.1
TX73_019255 -0.1
TX73_019650 +0.0
TX73_022390 +0.0
TX73_022490 -0.3
Trans-2-enoyl-CoA reductase (NAD(+)) (in reverse):
(2E)-hex-2-enoyl-CoA + NADH + H+→hexanoyl-CoA + NAD+ (EC 1.3.1.44)
No genes
hexanoyl-CoA + NAD(P)H + H+→1-hexanal + coenzyme A + NAD(P)+
No genes
1-hexanal + NADH + H+→hexan-1-ol + NAD+
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information