MetaCyc Pathway: palmitate biosynthesis II (type II fatty acid synthase) in Rhodopseudomonas palustris CGA009

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Reactions and Genes 4-Hydroxybenzoate (C)
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3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
an acetoacetyl-[acp] + NADPH + H+→a (3R)-3-hydroxybutanoyl-[acp] + NADP+ (EC 1.1.1.100)
TX73_000560 -0.2
TX73_002485 +0.2
TX73_003390 -4.1
TX73_004045 -0.0
TX73_004610 -0.1
TX73_004615 -0.2
TX73_008650 -0.1
TX73_008655 -0.0
TX73_008935 +0.1
TX73_011140 +0.1
TX73_012495 +0.1
TX73_015900 N.D.
TX73_016995 +0.0
TX73_017080 +0.0
TX73_017465 -0.1
TX73_017980 -0.1
TX73_018405 +0.1
TX73_018410 -0.1
TX73_020990 -0.5
TX73_023875 +0.3
TX73_024180 -0.0
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxybutanoyl-[acp]→a (2E)-but-2-enoyl-[acp] + H2O (EC 4.2.1.59)
TX73_002210 N.D.
TX73_010415 +0.1
TX73_015090 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-but-2-enoyl-[acp] + NADH + H+→a butanoyl-[acp] + NAD+ (EC 1.3.1.9)
TX73_002220 N.D.
TX73_006160 -0.0
TX73_010005 +0.1
TX73_011140 +0.1
TX73_016095 +0.1
TX73_023730 -0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
a butanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxohexanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
TX73_002215 N.D.
TX73_010405 N.D.
TX73_010410 N.D.
TX73_015890 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxohexanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyhexanoyl-[acp] + NADP+ (EC 1.1.1.100)
TX73_000560 -0.2
TX73_002485 +0.2
TX73_003390 -4.1
TX73_004045 -0.0
TX73_004610 -0.1
TX73_004615 -0.2
TX73_008650 -0.1
TX73_008655 -0.0
TX73_008935 +0.1
TX73_011140 +0.1
TX73_012495 +0.1
TX73_015900 N.D.
TX73_016995 +0.0
TX73_017080 +0.0
TX73_017465 -0.1
TX73_017980 -0.1
TX73_018405 +0.1
TX73_018410 -0.1
TX73_020990 -0.5
TX73_023875 +0.3
TX73_024180 -0.0
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyhexanoyl-[acp]→a (2E)-hex-2-enoyl-[acp] + H2O (EC 4.2.1.59)
TX73_002210 N.D.
TX73_010415 +0.1
TX73_015090 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-hex-2-enoyl-[acp] + NADH + H+→a hexanoyl-[acp] + NAD+ (EC 1.3.1.9)
TX73_002220 N.D.
TX73_006160 -0.0
TX73_010005 +0.1
TX73_011140 +0.1
TX73_016095 +0.1
TX73_023730 -0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
a hexanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxooctanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
TX73_002215 N.D.
TX73_010405 N.D.
TX73_010410 N.D.
TX73_015890 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxooctanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyoctanoyl-[acp] + NADP+ (EC 1.1.1.100)
TX73_000560 -0.2
TX73_002485 +0.2
TX73_003390 -4.1
TX73_004045 -0.0
TX73_004610 -0.1
TX73_004615 -0.2
TX73_008650 -0.1
TX73_008655 -0.0
TX73_008935 +0.1
TX73_011140 +0.1
TX73_012495 +0.1
TX73_015900 N.D.
TX73_016995 +0.0
TX73_017080 +0.0
TX73_017465 -0.1
TX73_017980 -0.1
TX73_018405 +0.1
TX73_018410 -0.1
TX73_020990 -0.5
TX73_023875 +0.3
TX73_024180 -0.0
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyoctanoyl-[acp]→a (2E)-oct-2-enoyl-[acp] + H2O (EC 4.2.1.59)
TX73_002210 N.D.
TX73_010415 +0.1
TX73_015090 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-oct-2-enoyl-[acp] + NADH + H+→an octanoyl-[acp] + NAD+ (EC 1.3.1.9)
TX73_002220 N.D.
TX73_006160 -0.0
TX73_010005 +0.1
TX73_011140 +0.1
TX73_016095 +0.1
TX73_023730 -0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
an octanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxodecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
TX73_002215 N.D.
TX73_010405 N.D.
TX73_010410 N.D.
TX73_015890 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxodecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxydecanoyl-[acp] + NADP+ (EC 1.1.1.100)
TX73_000560 -0.2
TX73_002485 +0.2
TX73_003390 -4.1
TX73_004045 -0.0
TX73_004610 -0.1
TX73_004615 -0.2
TX73_008650 -0.1
TX73_008655 -0.0
TX73_008935 +0.1
TX73_011140 +0.1
TX73_012495 +0.1
TX73_015900 N.D.
TX73_016995 +0.0
TX73_017080 +0.0
TX73_017465 -0.1
TX73_017980 -0.1
TX73_018405 +0.1
TX73_018410 -0.1
TX73_020990 -0.5
TX73_023875 +0.3
TX73_024180 -0.0
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydecanoyl-[acp]→a (2E)-dec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
TX73_002210 N.D.
TX73_010415 +0.1
TX73_015090 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-dec-2-enoyl-[acp] + NADH + H+→a decanoyl-[acp] + NAD+ (EC 1.3.1.9)
TX73_002220 N.D.
TX73_006160 -0.0
TX73_010005 +0.1
TX73_011140 +0.1
TX73_016095 +0.1
TX73_023730 -0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
a decanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxododecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
TX73_002215 N.D.
TX73_010405 N.D.
TX73_010410 N.D.
TX73_015890 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxododecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxydodecanoyl-[acp] + NADP+ (EC 1.1.1.100)
TX73_000560 -0.2
TX73_002485 +0.2
TX73_003390 -4.1
TX73_004045 -0.0
TX73_004610 -0.1
TX73_004615 -0.2
TX73_008650 -0.1
TX73_008655 -0.0
TX73_008935 +0.1
TX73_011140 +0.1
TX73_012495 +0.1
TX73_015900 N.D.
TX73_016995 +0.0
TX73_017080 +0.0
TX73_017465 -0.1
TX73_017980 -0.1
TX73_018405 +0.1
TX73_018410 -0.1
TX73_020990 -0.5
TX73_023875 +0.3
TX73_024180 -0.0
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydodecanoyl-[acp]→a (2E)-dodec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
TX73_002210 N.D.
TX73_010415 +0.1
TX73_015090 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-dodec-2-enoyl-[acp] + NADH + H+→a dodecanoyl-[acp] + NAD+ (EC 1.3.1.9)
TX73_002220 N.D.
TX73_006160 -0.0
TX73_010005 +0.1
TX73_011140 +0.1
TX73_016095 +0.1
TX73_023730 -0.2
Dodecanoyl-[acyl-carrier-protein] hydrolase:
a dodecanoyl-[acp][nil] + H2O[nil]→laurate[nil] + a soluble [acyl-carrier protein][nil] + H+[nil] (EC 3.1.2.21)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a dodecanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxotetradecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
TX73_002215 N.D.
TX73_010405 N.D.
TX73_010410 N.D.
TX73_015890 N.D.
Butyrate--CoA ligase:
laurate + ATP + coenzyme A→lauroyl-CoA + AMP + diphosphate (EC 6.2.1.2; 6.2.1.3)
TX73_002405 -0.1
TX73_006335 +0.1
TX73_006375 -0.0
TX73_009080 +0.0
TX73_011050 +0.0
TX73_011070 +0.1
TX73_017055 -0.1
TX73_017935 +0.1
TX73_019250 -0.1
TX73_020940 -0.1
TX73_022105 -1.6
TX73_025065 -0.0
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxotetradecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxytetradecanoyl-[acp] + NADP+ (EC 1.1.1.100)
TX73_000560 -0.2
TX73_002485 +0.2
TX73_003390 -4.1
TX73_004045 -0.0
TX73_004610 -0.1
TX73_004615 -0.2
TX73_008650 -0.1
TX73_008655 -0.0
TX73_008935 +0.1
TX73_011140 +0.1
TX73_012495 +0.1
TX73_015900 N.D.
TX73_016995 +0.0
TX73_017080 +0.0
TX73_017465 -0.1
TX73_017980 -0.1
TX73_018405 +0.1
TX73_018410 -0.1
TX73_020990 -0.5
TX73_023875 +0.3
TX73_024180 -0.0
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxytetradecanoyl-[acp]→a (2E)-tetradec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
TX73_002210 N.D.
TX73_010415 +0.1
TX73_015090 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-tetradec-2-enoyl-[acp] + NADH + H+→a myristoyl-[acp] + NAD+ (EC 1.3.1.9)
TX73_002220 N.D.
TX73_006160 -0.0
TX73_010005 +0.1
TX73_011140 +0.1
TX73_016095 +0.1
TX73_023730 -0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
a myristoyl-[acp] + a malonyl-[acp] + H+→a 3-oxohexadecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
TX73_002215 N.D.
TX73_010405 N.D.
TX73_010410 N.D.
TX73_015890 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxohexadecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyhexadecanoyl-[acp] + NADP+ (EC 1.1.1.100)
TX73_000560 -0.2
TX73_002485 +0.2
TX73_003390 -4.1
TX73_004045 -0.0
TX73_004610 -0.1
TX73_004615 -0.2
TX73_008650 -0.1
TX73_008655 -0.0
TX73_008935 +0.1
TX73_011140 +0.1
TX73_012495 +0.1
TX73_015900 N.D.
TX73_016995 +0.0
TX73_017080 +0.0
TX73_017465 -0.1
TX73_017980 -0.1
TX73_018405 +0.1
TX73_018410 -0.1
TX73_020990 -0.5
TX73_023875 +0.3
TX73_024180 -0.0
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyhexadecanoyl-[acp]→a (2E)-hexadec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
TX73_002210 N.D.
TX73_010415 +0.1
TX73_015090 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-hexadec-2-enoyl-[acp] + NADH + H+→a palmitoyl-[acp] + NAD+ (EC 1.3.1.9)
TX73_002220 N.D.
TX73_006160 -0.0
TX73_010005 +0.1
TX73_011140 +0.1
TX73_016095 +0.1
TX73_023730 -0.2
Oleoyl-[acyl-carrier-protein] hydrolase:
a palmitoyl-[acp] + H2O→palmitate + a soluble [acyl-carrier protein] + H+ (EC 3.1.2.14)
No genes
Long-chain-fatty-acid--CoA ligase:
palmitate + ATP + coenzyme A→palmitoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
TX73_001145 +0.0
TX73_002405 -0.1
TX73_006335 +0.1
TX73_006375 -0.0
TX73_009080 +0.0
TX73_011050 +0.0
TX73_011070 +0.1
TX73_017055 -0.1
TX73_017935 +0.1
TX73_019250 -0.1
TX73_020940 -0.1
TX73_022105 -1.6
TX73_025065 -0.0

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information