MetaCyc Pathway: capsaicin biosynthesis in Rhodopseudomonas palustris CGA009

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Reactions and Genes 4-Hydroxybenzoate (C)
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Caffeoyl-CoA O-methyltransferase:
(E)-caffeoyl-CoA + S-adenosyl-L-methionine→feruloyl-CoA + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.104)
No genes
isobutanoyl-CoA + 2 a malonyl-[acp] + 9 NADPH + 10 H+→(E)-8-methylnon-6-enoate + 2 a soluble [acyl-carrier protein] + coenzyme A + 9 NADP+ + 5 H2O
No genes
feruloyl-CoA + H2O→3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA (EC 4.1.2.61)
No genes
Long-chain-fatty-acid--CoA ligase:
(E)-8-methylnon-6-enoate + ATP + coenzyme A→(E)-8-methylnon-6-enoyl-CoA + ADP + phosphate (EC 6.2.1.3)
TX73_002405 -0.1
TX73_006335 +0.1
TX73_006375 -0.0
TX73_009080 +0.0
TX73_011050 +0.0
TX73_011070 +0.1
TX73_017055 -0.1
TX73_017935 +0.1
TX73_019250 -0.1
TX73_020940 -0.1
TX73_022105 -1.6
TX73_025065 -0.0
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA→vanillin + acetyl-CoA (EC 4.1.2.61)
No genes
vanillin + L-alanine→vanillylamine + pyruvate (EC 2.6.1.119)
No genes
(E)-8-methylnon-6-enoyl-CoA + vanillylamine→capsaicin + coenzyme A + H+ (EC 2.3.2.35)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information