MetaCyc Pathway: phenylacetate degradation I (aerobic) in Rhodopseudomonas palustris CGA009

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Reactions and Genes 4-Hydroxybenzoate (C)
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Phenylacetate--CoA ligase:
phenylacetate + ATP + coenzyme A→phenylacetyl-CoA + AMP + diphosphate (EC 6.2.1.30)
TX73_006310 +0.0
TX73_007335 -0.0
TX73_008865 +0.0
phenylacetyl-CoA + NADPH + dioxygen + H+→2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP+ + H2O (EC 1.14.13.149)
TX73_019500 +0.2
TX73_019505 -0.0
TX73_019510 +0.1
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA→2-oxepin-2(3H)-ylideneacetyl-CoA (EC 5.3.3.18)
No genes
2-oxepin-2(3H)-ylideneacetyl-CoA + H2O→3-oxo-5,6-didehydrosuberyl-CoA semialdehyde (EC 3.3.2.12)
No genes
3-oxo-5,6-didehydrosuberyl-CoA semialdehyde + NADP+ + H2O→3-oxo-5,6-didehydrosuberyl-CoA + NADPH + 2 H+ (EC 1.2.1.91)
No genes
3-oxo-5,6-didehydrosuberyl-CoA + coenzyme A→(2E)-5-carboxy-2-pentenoyl-CoA + acetyl-CoA (EC 2.3.1.223)
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H2O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)
TX73_001990 +0.1
TX73_002165 -0.0
TX73_002395 -0.1
TX73_002500 +0.5
TX73_002510 +0.3
TX73_003370 +0.0
TX73_003500 +0.2
TX73_004220 +0.3
TX73_004930 -0.1
TX73_006355 -0.1
TX73_007240 +0.1
TX73_008780 -0.1
TX73_008810 +0.1
TX73_009040 -0.1
TX73_009055 -0.1
TX73_009075 +0.2
TX73_009185 +0.1
TX73_009315 +2.1
TX73_011065 +0.2
TX73_011975 -0.2
TX73_014325 -0.2
TX73_017085 -0.3
TX73_017810 +0.1
TX73_017840 +2.2
TX73_017875 -0.4
TX73_019255 -0.3
TX73_019650 -0.0
TX73_022390 -0.0
TX73_022490 +0.3
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipoyl-CoA + NADH + H+ (EC 1.1.1.35)
TX73_004220 +0.3
TX73_008775 -0.2
TX73_011910 +0.1
TX73_018155 -0.2
TX73_019255 -0.3
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)
TX73_002660 -0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information