MetaCyc Pathway: oleate β-oxidation in Rhodopseudomonas palustris CGA009

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Reactions and Genes 4-Hydroxybenzoate (C)
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Long-chain-fatty-acid--CoA ligase:
oleate + ATP + coenzyme A→oleoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
TX73_002405 +0.1
TX73_006335 -0.0
TX73_006375 -0.1
TX73_009080 +0.3
TX73_011050 +0.1
TX73_011070 +0.0
TX73_017055 -0.2
TX73_017935 -0.2
TX73_019250 +0.0
TX73_020940 -0.2
TX73_022105 -2.0
TX73_025065 +0.1
oleoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E,9Z)-octadec-2,9-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.8)
No genes
Enoyl-CoA hydratase (in reverse):
(2E,9Z)-octadec-2,9-enoyl-CoA + H2O→(S)-3-hydroxy-(9Z)-octadecenoyl-CoA (EC 4.2.1.17)
TX73_001990 +0.1
TX73_002165 -0.0
TX73_002395 -0.1
TX73_002500 +0.5
TX73_002510 +0.3
TX73_003370 +0.0
TX73_003500 +0.2
TX73_004220 +0.3
TX73_004930 -0.1
TX73_006355 -0.1
TX73_007240 +0.1
TX73_008780 -0.1
TX73_008810 +0.1
TX73_009040 -0.1
TX73_009055 -0.1
TX73_009075 +0.2
TX73_009185 +0.1
TX73_009315 +2.1
TX73_011065 +0.2
TX73_011975 -0.2
TX73_014325 -0.2
TX73_017085 -0.3
TX73_017810 +0.1
TX73_017840 +2.2
TX73_017875 -0.4
TX73_019255 -0.3
TX73_019650 -0.0
TX73_022390 -0.0
TX73_022490 +0.3
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxy-(9Z)-octadecenoyl-CoA + NAD+→3-oxo-(9Z)-octadecenoyl-CoA + NADH + H+ (EC 1.1.1.35)
TX73_004220 +0.3
TX73_008775 -0.2
TX73_011910 +0.1
TX73_018155 -0.2
TX73_019255 -0.3
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-(9Z)-octadecenoyl-CoA + coenzyme A→acetyl-CoA + (7Z)-hexadecenoyl-CoA (EC 2.3.1.16)
TX73_002660 -0.0
TX73_002750 -0.6
TX73_004215 +0.3
TX73_008765 -0.0
TX73_011915 +0.7
TX73_017920 +0.0
TX73_017940 +0.1
TX73_019245 -0.1
TX73_022530 -0.2
(7Z)-hexadecenoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E,7Z)-hexadec-2,7-dienoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.8)
No genes
Enoyl-CoA hydratase (in reverse):
(2E,7Z)-hexadec-2,7-dienoyl-CoA + H2O→(S)-3-hydroxy-(7Z)-hexadecenoyl-CoA (EC 4.2.1.17)
TX73_001990 +0.1
TX73_002165 -0.0
TX73_002395 -0.1
TX73_002500 +0.5
TX73_002510 +0.3
TX73_003370 +0.0
TX73_003500 +0.2
TX73_004220 +0.3
TX73_004930 -0.1
TX73_006355 -0.1
TX73_007240 +0.1
TX73_008780 -0.1
TX73_008810 +0.1
TX73_009040 -0.1
TX73_009055 -0.1
TX73_009075 +0.2
TX73_009185 +0.1
TX73_009315 +2.1
TX73_011065 +0.2
TX73_011975 -0.2
TX73_014325 -0.2
TX73_017085 -0.3
TX73_017810 +0.1
TX73_017840 +2.2
TX73_017875 -0.4
TX73_019255 -0.3
TX73_019650 -0.0
TX73_022390 -0.0
TX73_022490 +0.3
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxy-(7Z)-hexadecenoyl-CoA + NAD+→3-oxo-(7Z)-hexadecenoyl-CoA + NADH + H+ (EC 1.1.1.35)
TX73_004220 +0.3
TX73_008775 -0.2
TX73_011910 +0.1
TX73_018155 -0.2
TX73_019255 -0.3
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-(7Z)-hexadecenoyl-CoA + coenzyme A→acetyl-CoA + (5Z)-tetradecenoyl-CoA (EC 2.3.1.16)
TX73_002660 -0.0
TX73_002750 -0.6
TX73_004215 +0.3
TX73_008765 -0.0
TX73_011915 +0.7
TX73_017920 +0.0
TX73_017940 +0.1
TX73_019245 -0.1
TX73_022530 -0.2
(5Z)-tetradecenoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E,5Z)-tetradec-2,5-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.8)
No genes
Dodecenoyl-CoA isomerase:
(2E,5Z)-tetradec-2,5-enoyl-CoA→(3E,5Z)-tetradeca-3,5-dienoyl-CoA (EC 5.3.3.8)
TX73_019255 -0.3
Enoyl-CoA hydratase (in reverse):
(2E,5Z)-tetradec-2,5-enoyl-CoA + H2O→(S)-3-hydroxy-(5Z)-tetradecenoyl-CoA (EC 4.2.1.17)
TX73_001990 +0.1
TX73_002165 -0.0
TX73_002395 -0.1
TX73_002500 +0.5
TX73_002510 +0.3
TX73_003370 +0.0
TX73_003500 +0.2
TX73_004220 +0.3
TX73_004930 -0.1
TX73_006355 -0.1
TX73_007240 +0.1
TX73_008780 -0.1
TX73_008810 +0.1
TX73_009040 -0.1
TX73_009055 -0.1
TX73_009075 +0.2
TX73_009185 +0.1
TX73_009315 +2.1
TX73_011065 +0.2
TX73_011975 -0.2
TX73_014325 -0.2
TX73_017085 -0.3
TX73_017810 +0.1
TX73_017840 +2.2
TX73_017875 -0.4
TX73_019255 -0.3
TX73_019650 -0.0
TX73_022390 -0.0
TX73_022490 +0.3
Long-chain-3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxy-(5Z)-tetradecenoyl-CoA + NAD+→3-oxo-(5Z)-tetradecenoyl-CoA + NADH + H+ (EC 1.1.1.211; 1.1.1.35)
TX73_004220 +0.3
TX73_008775 -0.2
TX73_011910 +0.1
TX73_018155 -0.2
TX73_019255 -0.3
(3E,5Z)-tetradeca-3,5-dienoyl-CoA + H2O→(3E,5Z)-tetradeca-3,5-dienoate + coenzyme A + H+
No genes
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-(5Z)-tetradecenoyl-CoA + coenzyme A→acetyl-CoA + (3Z)-dodec-3-enoyl-CoA (EC 2.3.1.16)
TX73_002660 -0.0
TX73_002750 -0.6
TX73_004215 +0.3
TX73_008765 -0.0
TX73_011915 +0.7
TX73_017920 +0.0
TX73_017940 +0.1
TX73_019245 -0.1
TX73_022530 -0.2
Dodecenoyl-CoA isomerase:
(3Z)-dodec-3-enoyl-CoA→(2E)-dodec-2-enoyl-CoA (EC 5.3.3.8)
TX73_019255 -0.3
Long-chain-enoyl-CoA hydratase (in reverse):
(2E)-dodec-2-enoyl-CoA + H2O→(S)-3-hydroxydodecanoyl-CoA (EC 4.2.1.74)
No genes
Long-chain-3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxydodecanoyl-CoA + NAD+→3-oxododecanoyl-CoA + NADH + H+ (EC 1.1.1.211; 1.1.1.35)
TX73_004220 +0.3
TX73_008775 -0.2
TX73_011910 +0.1
TX73_018155 -0.2
TX73_019255 -0.3
Acetyl-CoA C-acyltransferase (in reverse):
3-oxododecanoyl-CoA + coenzyme A→acetyl-CoA + decanoyl-CoA (EC 2.3.1.16)
TX73_002660 -0.0
TX73_002750 -0.6
TX73_004215 +0.3
TX73_008765 -0.0
TX73_011915 +0.7
TX73_017920 +0.0
TX73_017940 +0.1
TX73_019245 -0.1
TX73_022530 -0.2
decanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-dec-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
TX73_003050 -0.0
TX73_004025 -0.3
TX73_004210 +1.2
TX73_004935 +0.4
TX73_008745 +0.0
TX73_016110 -0.1
TX73_017005 +0.5
TX73_020735 -0.2
Long-chain-enoyl-CoA hydratase (in reverse):
(2E)-dec-2-enoyl-CoA + H2O→(S)-3-hydroxydecanoyl-CoA (EC 4.2.1.74)
TX73_001990 +0.1
TX73_002165 -0.0
TX73_002395 -0.1
TX73_002500 +0.5
TX73_002510 +0.3
TX73_003370 +0.0
TX73_004930 -0.1
TX73_006355 -0.1
TX73_007240 +0.1
TX73_008810 +0.1
TX73_009040 -0.1
TX73_009055 -0.1
TX73_009185 +0.1
TX73_009315 +2.1
TX73_011975 -0.2
TX73_014325 -0.2
TX73_017085 -0.3
TX73_019255 -0.3
TX73_019650 -0.0
TX73_022390 -0.0
TX73_022490 +0.3
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxydecanoyl-CoA + NAD+→3-oxodecanoyl-CoA + NADH + H+ (EC 1.1.1.35)
TX73_004220 +0.3
TX73_008775 -0.2
TX73_011910 +0.1
TX73_018155 -0.2
TX73_019255 -0.3
Acetyl-CoA C-acyltransferase (in reverse):
3-oxodecanoyl-CoA + coenzyme A→acetyl-CoA + octanoyl-CoA (EC 2.3.1.16)
TX73_002660 -0.0
TX73_002750 -0.6
TX73_004215 +0.3
TX73_008765 -0.0
TX73_011915 +0.7
TX73_017920 +0.0
TX73_017940 +0.1
TX73_019245 -0.1
TX73_022530 -0.2
octanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-oct-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
TX73_003050 -0.0
TX73_004025 -0.3
TX73_004210 +1.2
TX73_004935 +0.4
TX73_008745 +0.0
TX73_016110 -0.1
TX73_017005 +0.5
TX73_020735 -0.2
Long-chain-enoyl-CoA hydratase (in reverse):
(2E)-oct-2-enoyl-CoA + H2O→(3S)-3-hydroxyoctanoyl-CoA (EC 4.2.1.74)
No genes
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxyoctanoyl-CoA + NAD+→3-oxooctanoyl-CoA + NADH + H+ (EC 1.1.1.35)
TX73_004220 +0.3
TX73_008775 -0.2
TX73_011910 +0.1
TX73_018155 -0.2
TX73_019255 -0.3
Acetyl-CoA C-acyltransferase (in reverse):
3-oxooctanoyl-CoA + coenzyme A→acetyl-CoA + hexanoyl-CoA (EC 2.3.1.16)
TX73_002660 -0.0
TX73_002750 -0.6
TX73_004215 +0.3
TX73_008765 -0.0
TX73_011915 +0.7
TX73_017920 +0.0
TX73_017940 +0.1
TX73_019245 -0.1
TX73_022530 -0.2
hexanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-hex-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
TX73_003050 -0.0
TX73_004025 -0.3
TX73_004210 +1.2
TX73_004935 +0.4
TX73_008745 +0.0
TX73_016110 -0.1
TX73_017005 +0.5
TX73_020735 -0.2
Long-chain-enoyl-CoA hydratase (in reverse):
(2E)-hex-2-enoyl-CoA + H2O→(S)-3-hydroxyhexanoyl-CoA (EC 4.2.1.74)
TX73_001990 +0.1
TX73_002165 -0.0
TX73_002395 -0.1
TX73_002500 +0.5
TX73_002510 +0.3
TX73_003370 +0.0
TX73_004930 -0.1
TX73_006355 -0.1
TX73_007240 +0.1
TX73_008810 +0.1
TX73_009040 -0.1
TX73_009055 -0.1
TX73_009185 +0.1
TX73_009315 +2.1
TX73_011975 -0.2
TX73_014325 -0.2
TX73_017085 -0.3
TX73_019255 -0.3
TX73_019650 -0.0
TX73_022390 -0.0
TX73_022490 +0.3
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxyhexanoyl-CoA + NAD+→3-oxohexanoyl-CoA + NADH + H+ (EC 1.1.1.35)
TX73_004220 +0.3
TX73_008775 -0.2
TX73_011910 +0.1
TX73_018155 -0.2
TX73_019255 -0.3
Acetyl-CoA C-acyltransferase (in reverse):
3-oxohexanoyl-CoA + coenzyme A→acetyl-CoA + butanoyl-CoA (EC 2.3.1.16; 2.3.1.9)
TX73_002660 -0.0
TX73_002750 -0.6
TX73_004215 +0.3
TX73_008765 -0.0
TX73_009030 +0.1
TX73_011915 +0.7
TX73_016520 +0.0
TX73_017920 +0.0
TX73_017940 +0.1
TX73_019245 -0.1
TX73_022530 -0.2
butanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→crotonyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
No genes
crotonyl-CoA + H2O→(S)-3-hydroxybutanoyl-CoA (EC 4.2.1.150)
TX73_001990 +0.1
TX73_002165 -0.0
TX73_002395 -0.1
TX73_002500 +0.5
TX73_002510 +0.3
TX73_003370 +0.0
TX73_004930 -0.1
TX73_006355 -0.1
TX73_007240 +0.1
TX73_008810 +0.1
TX73_009040 -0.1
TX73_009055 -0.1
TX73_009185 +0.1
TX73_009315 +2.1
TX73_011975 -0.2
TX73_014325 -0.2
TX73_017085 -0.3
TX73_019255 -0.3
TX73_019650 -0.0
TX73_022390 -0.0
TX73_022490 +0.3
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD+→acetoacetyl-CoA + NADH + H+ (EC 1.1.1.35)
TX73_004220 +0.3
TX73_008775 -0.2
TX73_011910 +0.1
TX73_018155 -0.2
TX73_019255 -0.3
TX73_024670 +1.4
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
TX73_002660 -0.0
TX73_002750 -0.6
TX73_004215 +0.3
TX73_008765 -0.0
TX73_009030 +0.1
TX73_011915 +0.7
TX73_016520 +0.0
TX73_017920 +0.0
TX73_017940 +0.1
TX73_019245 -0.1
TX73_022530 -0.2

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information