MetaCyc Pathway: 2-methyl-branched fatty acid β-oxidation in Rhodopseudomonas palustris CGA009

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Reactions and Genes 4-Hydroxybenzoate (C)
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Butyrate--CoA ligase:
a short-chain 2-methyl-branched fatty acid + ATP + coenzyme A→a short-chain 2-methyl fatty acyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
a long-chain 2-methyl fatty acyl-CoA + an oxidized electron-transfer flavoprotein + H+→a long-chain (2E)-2-methyl-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.8)
No genes
Butyrate--CoA ligase:
a medium-chain 2-methyl-branched fatty acid + ATP + coenzyme A→a medium-chain 2-methyl fatty acyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
a short-chain 2-methyl fatty acyl-CoA + an oxidized electron-transfer flavoprotein + H+→a short-chain (2E)-2-methyl-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
a medium-chain 2-methyl fatty acyl-CoA + an oxidized electron-transfer flavoprotein + H+→a medium-chain (2E)-2-methyl-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
TX73_003050 -0.0
TX73_004025 -0.3
TX73_004210 +1.2
TX73_004935 +0.4
TX73_008745 +0.0
TX73_016110 -0.1
TX73_017005 +0.5
TX73_020735 -0.2
Enoyl-CoA hydratase (in reverse):
a long-chain (2E)-2-methyl-2-enoyl-CoA + H2O→a long-chain (3S)-3-hydroxy-2-methylacyl-CoA (EC 4.2.1.17)
TX73_001990 +0.1
TX73_002165 -0.0
TX73_002395 -0.1
TX73_002500 +0.5
TX73_002510 +0.3
TX73_003370 +0.0
TX73_003500 +0.2
TX73_004220 +0.3
TX73_004930 -0.1
TX73_006355 -0.1
TX73_007240 +0.1
TX73_008780 -0.1
TX73_008810 +0.1
TX73_009040 -0.1
TX73_009055 -0.1
TX73_009075 +0.2
TX73_009185 +0.1
TX73_009315 +2.1
TX73_011065 +0.2
TX73_011975 -0.2
TX73_014325 -0.2
TX73_017085 -0.3
TX73_017810 +0.1
TX73_017840 +2.2
TX73_017875 -0.4
TX73_019255 -0.3
TX73_019650 -0.0
TX73_022390 -0.0
TX73_022490 +0.3
Enoyl-CoA hydratase (in reverse):
a short-chain (2E)-2-methyl-2-enoyl-CoA + H2O→a short-chain (3S)-3-hydroxy-2-methylacyl-CoA (EC 4.2.1.17)
TX73_001990 +0.1
TX73_002165 -0.0
TX73_002395 -0.1
TX73_002500 +0.5
TX73_002510 +0.3
TX73_003370 +0.0
TX73_003500 +0.2
TX73_004220 +0.3
TX73_004930 -0.1
TX73_006355 -0.1
TX73_007240 +0.1
TX73_008780 -0.1
TX73_008810 +0.1
TX73_009040 -0.1
TX73_009055 -0.1
TX73_009075 +0.2
TX73_009185 +0.1
TX73_009315 +2.1
TX73_011065 +0.2
TX73_011975 -0.2
TX73_014325 -0.2
TX73_017085 -0.3
TX73_017810 +0.1
TX73_017840 +2.2
TX73_017875 -0.4
TX73_019255 -0.3
TX73_019650 -0.0
TX73_022390 -0.0
TX73_022490 +0.3
Enoyl-CoA hydratase (in reverse):
a medium-chain (2E)-2-methyl-2-enoyl-CoA + H2O→a medium-chain (3S)-3-hydroxy-2-methylacyl-CoA (EC 4.2.1.17)
TX73_001990 +0.1
TX73_002165 -0.0
TX73_002395 -0.1
TX73_002500 +0.5
TX73_002510 +0.3
TX73_003370 +0.0
TX73_003500 +0.2
TX73_004220 +0.3
TX73_004930 -0.1
TX73_006355 -0.1
TX73_007240 +0.1
TX73_008780 -0.1
TX73_008810 +0.1
TX73_009040 -0.1
TX73_009055 -0.1
TX73_009075 +0.2
TX73_009185 +0.1
TX73_009315 +2.1
TX73_011065 +0.2
TX73_011975 -0.2
TX73_014325 -0.2
TX73_017085 -0.3
TX73_017810 +0.1
TX73_017840 +2.2
TX73_017875 -0.4
TX73_019255 -0.3
TX73_019650 -0.0
TX73_022390 -0.0
TX73_022490 +0.3
3-hydroxyacyl-CoA dehydrogenase:
a long-chain (3S)-3-hydroxy-2-methylacyl-CoA + NAD+→a long-chain 2-methyl-3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.35)
TX73_004220 +0.3
TX73_008775 -0.2
TX73_011910 +0.1
TX73_018155 -0.2
TX73_019255 -0.3
3-hydroxy-2-methylbutyryl-CoA dehydrogenase:
a short-chain (3S)-3-hydroxy-2-methylacyl-CoA + NAD+→a short-chain 2-methyl-3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.178)
TX73_008775 -0.2
3-hydroxyacyl-CoA dehydrogenase:
a medium-chain (3S)-3-hydroxy-2-methylacyl-CoA + NAD+→a medium-chain 2-methyl-3-oxoacyl-CoA + NADH + H+ (EC 1.1.1.35)
TX73_004220 +0.3
TX73_008775 -0.2
TX73_011910 +0.1
TX73_018155 -0.2
TX73_019255 -0.3
Acetyl-CoA C-acyltransferase (in reverse):
a long-chain 2-methyl-3-oxoacyl-CoA + coenzyme A→a long-chain 2-methyl fatty acyl-CoA + propanoyl-CoA (EC 2.3.1.16)
TX73_002660 -0.0
TX73_002750 -0.6
TX73_004215 +0.3
TX73_008765 -0.0
TX73_011915 +0.7
TX73_017920 +0.0
TX73_017940 +0.1
TX73_019245 -0.1
TX73_022530 -0.2
Acetyl-CoA C-acyltransferase (in reverse):
a short-chain 2-methyl-3-oxoacyl-CoA + coenzyme A→a short-chain 2-methyl fatty acyl-CoA + propanoyl-CoA (EC 2.3.1.16)
TX73_002660 -0.0
TX73_002750 -0.6
TX73_004215 +0.3
TX73_008765 -0.0
TX73_011915 +0.7
TX73_017920 +0.0
TX73_017940 +0.1
TX73_019245 -0.1
TX73_022530 -0.2
Acetyl-CoA C-acyltransferase (in reverse):
a medium-chain 2-methyl-3-oxoacyl-CoA + coenzyme A→a medium-chain 2-methyl fatty acyl-CoA + propanoyl-CoA (EC 2.3.1.16)
TX73_002660 -0.0
TX73_002750 -0.6
TX73_004215 +0.3
TX73_008765 -0.0
TX73_011915 +0.7
TX73_017920 +0.0
TX73_017940 +0.1
TX73_019245 -0.1
TX73_022530 -0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information