MetaCyc Pathway: gondoate biosynthesis (anaerobic) in Rhodanobacter denitrificans FW104-10B01

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Reactions and Genes R2A with nitrate 250 mM
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Beta-ketoacyl-acyl-carrier-protein synthase II:
an oleoyl-[acp] + a malonyl-[acp] + H+→an (11Z)-3-oxo-icos-11-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
LRK54_RS01175 N.D.
LRK54_RS03015 -0.8
LRK54_RS09780 -1.2
LRK54_RS13915 -0.9
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
an (11Z)-3-oxo-icos-11-enoyl-[acp][cytosol] + NADPH[cytosol] + H+[cytosol]→a (3R,11Z)-3-hydroxy-icos-11-enoyl-[acp][cytosol] + NADP+[cytosol] (EC 1.1.1.100)
LRK54_RS00850 -0.1
LRK54_RS01185 N.D.
LRK54_RS02570 -0.3
LRK54_RS08150 +0.0
LRK54_RS09760 -0.7
LRK54_RS14225 -0.1
LRK54_RS15975 +0.0
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R,11Z)-3-hydroxy-icos-11-enoyl-[acp][cytosol]→a (2E,11Z)-icosa-2,11-dienoyl-[acp][cytosol] + H2O[cytosol] (EC 4.2.1.59)
LRK54_RS03305 N.D.
LRK54_RS13910 -1.2
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E,11Z)-icosa-2,11-dienoyl-[acp][cytosol] + NADH[cytosol] + H+[cytosol]→a gondoyl-[acp][cytosol] + NAD+[cytosol] (EC 1.3.1.9)
LRK54_RS02705 +0.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information