MetaCyc Pathway: superpathway of glycolysis and the Entner-Doudoroff pathway in Rahnella sp. WP5

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Reactions and Genes casaminos (C)
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Glucose-6-phosphate dehydrogenase:
D-glucopyranose 6-phosphate + NADP+→6-phospho D-glucono-1,5-lactone + NADPH + H+ (EC 1.1.1.49)
EX31_RS10630 N.D.
D-glucopyranose[out] + an [HPr protein]-Nπ-phospho-L-histidine[in]→D-glucopyranose 6-phosphate[in] + an [HPr]-L-histidine[in] (EC 2.7.1.199)
EX31_RS20190 -3.2
EX31_RS24475 +0.2
EX31_RS24690 -0.1
EX31_RS24695 +0.1
EX31_RS24700 +0.4
6-phosphogluconolactonase:
6-phospho D-glucono-1,5-lactone + H2O→D-gluconate 6-phosphate + H+ (EC 3.1.1.31)
EX31_RS23640 +0.1
Glucose-6-phosphate isomerase:
α-D-glucose 6-phosphate→β-D-fructofuranose 6-phosphate (EC 5.3.1.9)
EX31_RS11815 +0.3
6-phosphofructokinase:
β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.11)
EX31_RS13510 -0.2
EX31_RS14310 -0.1
Phosphogluconate dehydratase:
D-gluconate 6-phosphate→2-dehydro-3-deoxy-D-gluconate 6-phosphate + H2O (EC 4.2.1.12)
EX31_RS16630 +0.2
Fructose-bisphosphate aldolase:
β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)
EX31_RS01425 +0.3
EX31_RS21415 N.D.
Fructose-bisphosphatase:
β-D-fructofuranose 1,6-bisphosphate + H2O→β-D-fructofuranose 6-phosphate + phosphate (EC 3.1.3.11)
EX31_RS08670 -2.6
EX31_RS10785 -0.1
EX31_RS14275 -0.1
EX31_RS23635 +0.1
2-dehydro-3-deoxy-phosphogluconate aldolase:
2-dehydro-3-deoxy-D-gluconate 6-phosphate→D-glyceraldehyde 3-phosphate + pyruvate (EC 4.1.2.14; 4.1.2.55)
EX31_RS10625 +0.0
EX31_RS12370 -0.0
EX31_RS16625 -0.6
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
EX31_RS06280 N.D.
EX31_RS06915 -1.2
Triose-phosphate isomerase (in reverse):
glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)
EX31_RS14300 N.D.
Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
EX31_RS21410 N.D.
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
EX31_RS03970 -0.1
EX31_RS14360 +0.0
EX31_RS23555 N.D.
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.11)
EX31_RS23555 N.D.
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
EX31_RS07940 N.D.
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
EX31_RS10640 +0.5
EX31_RS13870 -0.6
Pyruvate, water dikinase:
pyruvate + ATP + H2O→phosphoenolpyruvate + AMP + 2 H+ + phosphate (EC 2.7.9.2)
EX31_RS13935 -1.8

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information