MetaCyc Pathway: superpathway of aromatic amino acid biosynthesis in Rhodanobacter denitrificans FW104-10B01

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Reactions and Genes R2A with m-arsenite 0.078125 mM
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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
LRK54_RS02730 -0.0
LRK54_RS03440 +0.1
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
LRK54_RS04310 N.D.
LRK54_RS10390 +0.0
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
LRK54_RS06795 -1.6
LRK54_RS16615 -2.3
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
LRK54_RS08595 -1.0
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
LRK54_RS04305 -1.3
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
LRK54_RS00390 N.D.
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
LRK54_RS01725 N.D.
Anthranilate synthase:
chorismate + L-glutamine→anthranilate + L-glutamate + H+ + pyruvate (EC 4.1.3.27)
LRK54_RS01170 +0.0
LRK54_RS11415 -1.6
LRK54_RS11560 -3.0
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
LRK54_RS00395 -0.7
LRK54_RS14055 -0.2
Prephenate dehydratase:
prephenate + H+→3-phenyl-2-oxopropanoate + CO2 + H2O (EC 4.2.1.51)
LRK54_RS00395 -0.7
Prephenate dehydrogenase:
prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)
LRK54_RS14055 -0.2
Anthranilate phosphoribosyltransferase (in reverse):
anthranilate + 5-phospho-α-D-ribose 1-diphosphate→N-(5-phosphoribosyl)-anthranilate + diphosphate (EC 2.4.2.18)
LRK54_RS11565 -2.4
Phosphoribosylanthranilate isomerase:
N-(5-phosphoribosyl)-anthranilate→1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (EC 5.3.1.24)
LRK54_RS01695 N.D.
Aspartate transaminase (in reverse):
3-phenyl-2-oxopropanoate + L-glutamate→L-phenylalanine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
LRK54_RS00725 +1.4
LRK54_RS00830 -0.1
LRK54_RS01370 -0.5
LRK54_RS01600 -1.8
LRK54_RS10340 -0.0
LRK54_RS10685 -0.1
LRK54_RS11155 -0.6
LRK54_RS12020 -0.6
Aspartate transaminase (in reverse):
3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
LRK54_RS00725 +1.4
LRK54_RS00830 -0.1
LRK54_RS01370 -0.5
LRK54_RS01600 -1.8
LRK54_RS10685 -0.1
LRK54_RS11155 -0.6
Indole-3-glycerol-phosphate synthase:
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+→(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O (EC 4.1.1.48)
LRK54_RS11570 -2.0
Indole-3-glycerol-phosphate lyase:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate→indole + D-glyceraldehyde 3-phosphate (EC 4.1.2.8; 4.2.1.20)
LRK54_RS01680 -3.1
LRK54_RS01685 -2.8
indole + L-serine→L-tryptophan + H2O (EC 4.2.1.122; 4.2.1.20)
LRK54_RS01680 -3.1
LRK54_RS01685 -2.8

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information